| 2型糖尿病并发周围神经病变患者外周血白细胞介素6的改变及其临床意义 |
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| 引用本文： | 沈颖,郑亚虹,陈明卫,许慕蓉,万丽娟,张群慧. 2型糖尿病并发周围神经病变患者外周血白细胞介素6的改变及其临床意义[J]. 中国临床保健杂志, 2017, 20(4): 373-375 |
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| 作者姓名： | 沈颖 郑亚虹 陈明卫 许慕蓉 万丽娟 张群慧 |
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| 作者单位： | ;1.安徽医科大学第一附属医院内分泌科 |
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| 基金项目： | 安徽省卫生厅临床重点项目(2010A008) |
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| 摘 要： | 目的探讨2型糖尿病周围神经病变(DPN)患者外周血白细胞介素6(IL-6)的改变及其临床意义。方法选取100例2型糖尿病患者,分为糖尿病周围神经病变组(DPN组)50例和无糖尿病周围神经病变组(NDPN组)50例,另选择50例健康人群作为对照组(NC组)。测定外周血IL-6含量,比较三组间IL-6水平差异;应用Pearson相关分析,探讨影响血清IL-6浓度的相关影响因素;应用Logistic回归分析,了解DPN发病的独立影响因素。结果 (1)T2DM组IL-6水平显著高于NC组,DPN组IL-6水平显著高于T2DM组(均P0.01);(2)Pearson相关分析显示,血清IL-6水平与运动及感觉神经传导速度均呈负相关(r值分别为-0.488,-0.389,均P0.05),与胰岛功能指数呈负相关(r=-0.384,P0.01)。Logistic回归分析发现体质量指数、收缩压、IL-6为DPN发病的独立危险因素。结论 2型糖尿病并发周围神经病变患者外周血IL-6水平明显增加,与DPN发病密切相关。
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| 关 键 词： | 糖尿病神经病变 白细胞介素6 生物学标记 危险因素 |
| 收稿时间： | 2017-03-18 |
The changes of serum interleukin 6 levels in patients with type 2 diabetes peripheral neuropathy and its clinical significance |
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| Shen Ying,Zhen Yahong,Chen Mingwei,Xu Murong,Wan Lijuan and Zhang Qunhui. The changes of serum interleukin 6 levels in patients with type 2 diabetes peripheral neuropathy and its clinical significance[J]. Chinese Journal of Clinical Healthcare, 2017, 20(4): 373-375 |
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| Authors: | Shen Ying Zhen Yahong Chen Mingwei Xu Murong Wan Lijuan Zhang Qunhui |
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| Affiliation: | Department of Endocrinology,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,China,Department of Endocrinology,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,China,Department of Endocrinology,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,China,Department of Endocrinology,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,China,Department of Endocrinology,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,China and Department of Endocrinology,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,China |
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| Abstract: | Objective To explore the changes of serum interleukin 6(IL-6)levels in patients with type 2 diabetes peripheral neuropathy (DPN) and its clinical significance.Methods A total of 100 patients with type 2 diabetes were divided into diabetic peripheral neuropathy(DPN)group(50 cases)and non-diabetic peripheral neuropathy(NDPN)group(50 cases).In addition,50 cases of healthy people were selected as control group (NC group).The serum level of IL-6 were detected and compared among three groups.Pearson correlation analysis was used to explore which factors influence on the serum level of IL-6.Logistic regression analysis were carried out to evaluate the independent influencing factors of DPN.Results (1) Serum level of IL-6 was higher in NDPN group than that in NC group ,Serum level of IL-6 was higher in DPN group than in NDPN group (P<0.01).(2) Pearson correlation analysis showed that the serum level of IL-6 was negatively correlated with both motor and sensory nerve conduction velocity (r=-0.488,r=-0.389,respectively,P<0.05),and also negatively correlated with islet function index (r=-0.384,P<0.01).Logistic analysis showed that body mass index,systolic blood pressure and IL-6 were independent risk factors for DPN.Conclusion The levels of IL-6 are increased significantly in patients with type 2 diabetes peripheral neuropathy and closely related to the development of DPN. |
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