Localisation of the MRX3 gene for non-specific X linked mental retardation. |
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| Authors: | A Gedeon B Kerr J Mulley G Turner |
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| Affiliation: | Department of Cytogenetics and Molecular Genetics, Adelaide Children's Hospital, Australia. |
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| Abstract: | A family is described with five affected males segregating a new gene for non-specific X linked mental retardation (MRX). Linkage analysis localised the gene at Xq28-qter. The maximum lod score was 2.89 with DXS52 (St14) at theta = 0.0. A recombinant was observed with DXS304 (U6.2) defining the proximal limit to the localisation. No evidence for linkage was determined using markers at several points along the remainder of the X chromosome, including the regions known to contain MRX1 and MRX2. This delineates the third gene for non-specific X linked mental retardation, MRX3. |
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