Mechanism and modification of bradykinin-induced coronary vasodilation. |
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| Authors: | P Needleman S L Key S E Denny P C Isakson Marshall GROUSI Missouri |
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| Affiliation: | P Needleman, S L Key, S E Denny, P C Isakson, and Marshall GROUSI, Missouri 63110 |
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| Abstract: | In isolated perfused rabbit hearts, bradykinin produced a concentration-dependent decrease in coronary resistance directly associated with biosynthesis and release of prostaglandin-E-like substance. An inhibitor of bradykinin destruction (the nonapeptide SQ-20881) markedly enhanced both the coronary vasodilation and release of prostaglandin-E-like substance produced by cardiac injection of bradykinin. Indomethacin inhibited both the myocardial prostaglandin biosynthesis and the decrease in coronary resistance induced by bradykinin. The demonstration that bradykinin is a potent stimulator of prostaglandin biosynthesis in the heart has implications as to the cause of the afferent cardiovascular reflexes and pain in myocardial infarction and angina pectoris. |
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