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山大颜抗老年痴呆作用的实验研究
引用本文:张金花,卢海啸,李家洲. 山大颜抗老年痴呆作用的实验研究[J]. 中国药师, 2011, 14(3): 365-366
作者姓名:张金花  卢海啸  李家洲
作者单位:1. 深圳市松岗人民医院药剂科,广东深圳,518105
2. 玉林师范学院化学与生物系
摘    要:目的:探讨山大颜对老年痴呆模型小鼠的作用。方法:采用跳台法分别测定不同剂量(50,200 mg·kg-1)山大颜提取物的抗老年痴呆活性。并对小鼠的血清超氧化物歧化酶(SOD)和脑内乙酰胆碱转移酶(ChAT)酶活力进行了测定。结果:山大颜能增强小鼠的记忆,并改善老年痴呆模型小鼠的血清SOD酶和脑内ChAT酶活力(P<0.01)。结论:山大颜有抗老年痴呆的作用。

关 键 词:山大颜  抗老年痴呆  超氧化物歧化酶  乙酰胆碱转移酶

Experimental Study on Anti-SDAT Effects of Psychotria rubra(Lour.) Poir
Zhang Jinhua,Lu Haixiao,Li Jiazhou. Experimental Study on Anti-SDAT Effects of Psychotria rubra(Lour.) Poir[J]. China Pharmacist, 2011, 14(3): 365-366
Authors:Zhang Jinhua  Lu Haixiao  Li Jiazhou
Affiliation:Zhang Jinhua~1,Lu Haixiao~2,Li Jiazhou~2(1.Department of Pharmacy,Shenzhen Songgang People's Hospital,Guangdong,Shenzhen 518105,China,2.Department of Chemistry and Biology,Yulin Normal University)
Abstract:Objective : To explore the anti-SDAT effects of Psychotria rubra ( Lour. ) Poir in mice. Method : The anti-SDAT activity of extractions from Psychotria rubra( Lour. ) Poir (50,200 mg·kg^-1 ) was studied by step clown test and determination of enzyme activity including serum SOD and brain ChAT in mice. Result: Psyehotria rubra ( Lour. ) Poir could increase memorization and enhance the enzyme activity of serum SOD and brain ChAT ( P 〈0. 01 ) in mice. Conclusion: Psychotria rubra( Lour. ) Poir has promising anti- SDAT effects
Keywords:Psychotria rubra(Lour.) Poir  Anti-SDAT  SOD  ChAT  
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