Evidence for biliary excretion of vancomycin into stool during intravenous therapy: potential implications for rectal colonization with vancomycin-resistant enterococci |
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| Authors: | Currie Brian P Lemos-Filho Luciano |
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| Affiliation: | Montefiore Medical Center, 111 E. 210th St., Bronx, NY 10467, USA. bcurrie@montefiore.org |
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| Abstract: | Sixty-three stool samples and five bile samples were prospectively collected from 33 patients receiving intravenous vancomycin therapy and were quantitatively analyzed for vancomycin by a competitive immunoassay. Vancomycin was excreted via bile into the stools of almost all patients at concentrations of 3.3 to 94.8 microg/ml after >/=5 days of a therapy of 1 g every 12 h. |
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