| 钛合金内固定材料修复脊柱结核：生物相容性及力学性能 |
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| 引用本文： | 庄 勇,尚显文,张 皓,刘 淼,许顺恩. 钛合金内固定材料修复脊柱结核：生物相容性及力学性能[J]. 中国组织工程研究, 2016, 20(30): 4509-4514. DOI: 10.3969/j.issn.2095-4344.2016.30.015 |
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| 作者姓名： | 庄 勇 尚显文 张 皓 刘 淼 许顺恩 |
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| 作者单位： | 贵州医科大学附属医院骨科，贵州省贵阳市 550001 |
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| 摘 要： |
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| 关 键 词： | 生物材料 骨生物材料 钛合金 不锈钢内固定材料 脊柱结核 生物相容性 力学性能 轴向拔出力 稳定性 |
| 收稿时间： | 2016-04-25 |
Implant fixation with titanium alloy repairs spinal tuberculosis: its biocompatibility and mechanical properties |
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| Zhuang Yong,Shang Xian-wen,Zhang Hao,Liu Miao,Xu Shun-en. Implant fixation with titanium alloy repairs spinal tuberculosis: its biocompatibility and mechanical properties[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(30): 4509-4514. DOI: 10.3969/j.issn.2095-4344.2016.30.015 |
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| Authors: | Zhuang Yong Shang Xian-wen Zhang Hao Liu Miao Xu Shun-en |
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| Affiliation: | Department of Orthopedics, Affiliated Hospital of Guizhou Medical University, Guiyang 550001, Guizhou Province, China |
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| Abstract: | BACKGROUND: Currently, surgical implant fixation is mainly applied for spinal tuberculosis. How to choose implant materials, however, is still under discussion. OBJECTIVE: To compare the biocompatibility and mechanical properties of titanium alloy and stainless steel for rabbit spinal tuberculosis.METHODS: Thirty rabbits were chosen to prepare spinal tuberculosis models. Then, the rabbits were equivalently randomized into two groups, which underwent implant fixation with stainless steel or titanium alloy, respectively. At 30 days after implantation, biocompatibility and biomechanical properties of the two materials in the repaired region of spine were observed and detected, respectively. RESULTS AND CONCLUSION: In view of the biocompatibility, infection and immunological rejection could not been found in the titanium alloy group; in contrast, infection appeared in three rabbits of the stainless steel group. Flexion, extension and lateral bending displacements under the spinal loading in the titanium alloy group were significantly less than those in the stainless steel group (P < 0.05); axial pull-out strength in the titanium alloy group was significantly higher than that in the stainless steel group (P < 0.05); flexion, extension, lateral bending and axial compression in the titanium alloy group were significantly greater than those in the stainless steel group (P < 0.05). In conclusion, titanium alloy material has good biocompatibility that can be used to restore and maintain the spinal stability. |
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| Keywords: | uberculosis Spinal Stainless Steel Biomechanics Tissue Engineering |
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