| 自体髂骨植骨联合自体骨髓干细胞移植治疗骨折术后骨不连 |
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| 引用本文： | 程 尹,鲁晓波,张 韵,应吕方. 自体髂骨植骨联合自体骨髓干细胞移植治疗骨折术后骨不连[J]. 中国组织工程研究, 2016, 20(51): 7605-7610. DOI: 10.3969/j.issn.2095-4344.2016.51.001 |
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| 作者姓名： | 程 尹 鲁晓波 张 韵 应吕方 |
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| 作者单位： | 西南医科大学附属医院，1骨与关节外科，2放射科，3脊柱外科，四川省泸州市 646000 |
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| 摘 要： | BACKGROUND: Bone nonunion is a common complication in the orthopedic treatment, and its morbidity reached 5%-10%, which results in the long-term functional disturbance of the limbs, and even disability. Autogenous iliac crest graft has been commonly used to treat bone nonunion, but some limitations still exist.OBJECTIVE: To investigate the treatment outcomes of autogenous iliac crest graft combined with autologous bone marrow stem cell transplantation for bone nonunion after fracture surgery. METHODS: Clinical and follow-up data from 69 patients with bone nonunion were analyzed retrospectively. All patients were allotted to combination (n=37) and iliac (n=32) groups, followed by treated with autologous iliac crest graft combined with autologous bone marrow stem cell transplantation or autologous crest graft, respectively. Afterwards, the hospitalization time, fracture healing time, bone mineral density and Fereadez-Esteve callus scores were detected and compared between groups.RESULTS AND CONCLUSION: The hospitalization time did not differ significantly between groups (P > 0.05). The fracture healing time in the combination group was significantly shortened compared with the iliac group (P < 0.05). The bone mineral density and Fereadez-Esteve callus scores in the combination group were significantly higher than those in the iliac group at 3 and 6 months after surgery (P < 0.05). The excellent and good rate of the affected limb function in the combination group was significantly higher than that in the iliac group (P < 0.05). These results suggest that autogenous iliac crest graft combined with autologous bone marrow stem cell transplantation for bone nonunion can accelerate fracture healing, promote porosis and improve the functional recovery of affected limbs.中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程
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| 关 键 词： | 组织构建 骨组织工程 自体髂骨植骨 自体骨髓干细胞移植 骨折 骨不连 |
| 收稿时间： | 2016-09-12 |
Autologous iliac crest graft combined with autologous bone marrow stem cell transplantation for bone nonunion after fracture surgery |
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| Cheng Yin,Lu Xiao-bo,Zhang Yun,Ying Lv-fang. Autologous iliac crest graft combined with autologous bone marrow stem cell transplantation for bone nonunion after fracture surgery[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(51): 7605-7610. DOI: 10.3969/j.issn.2095-4344.2016.51.001 |
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| Authors: | Cheng Yin Lu Xiao-bo Zhang Yun Ying Lv-fang |
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| Affiliation: | 1Department of Bone and Joint Surgery, 2Departmnet of Radiology, 3Departmnet of Spine Surgery, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan Province, China |
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| Abstract: | |
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| Keywords: | Fractures Ununited Bone Transplantation Ilium Bone Marrow Cells Tissue Engineering |
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