| 针灸对脑性瘫痪幼鼠模型行为学的影响及其机制 |
| |
| 引用本文： | 娄元俊,刘 阳,单海军,曹彩红,介小素. 针灸对脑性瘫痪幼鼠模型行为学的影响及其机制[J]. 中国组织工程研究, 2016, 20(49): 7314-7319. DOI: 10.3969/j.issn.2095-4344.2016.49.003 |
| |
| 作者姓名： | 娄元俊 刘 阳 单海军 曹彩红 介小素 |
| |
| 作者单位： | 1河南中医学院第二附属医院儿童康复科，河南省郑州市 450000；2河南中医学院研究生处，河南省郑州市 450000 |
| |
| 基金项目： | 河南中医学院苗圃工程项目(MP2011-16) |
| |
| 摘 要： | ![]()
BACKGROUND: Acupuncture of “Xingnao Kaiqiao” can treat cerebral palsy by increasing cerebral blood flow, decreasing inflammatory reaction and promoting cerebral nerve repair.OBJECTIVE:To explore the influence of acupuncture of “Xingnao Kaiqiao” on behavior of immature rats with cerebral palsy and the underlying mechanism.METHODS: (1) The immature rat model of cerebral palsy was established and then randomized into control, model and acupuncture groups. (2) The immature rats in the acupuncture group were treated with acupuncture at major points of Neiguan (P 6), Renzhong (Du 26) and Sanyinjiao (Sp 6), as well as auxiliary points of Jiquan (H 1), Chize (Lu 5) and Weizhong (UB 40), while the model and control groups received no intervention. (3) Twenty-four days later, the body mass and the time removing the mackintosh at forepassed center were measured and recorded, the spatial learning and memory ability was detected by Mortis water maze test, and the serum levels of tumor necrosis factor alpha and interleukin-6 were detected by ELISA. RESULTS AND CONCLUSION: (1) The order of the body mass gained was as follows: control group > acupuncture group > model group (P < 0.05). (2) The time removing the mackintosh at forepassed center was the longest in the model group, followed by the acupuncture group, and shortest in the control group (P < 0.05). (3) Acupuncture method significantly improved the cognitive ability of immature rats, and reduced the latency of searching for platform and swimming distance compared with the model group (P < 0.05). (4) The serum levels of tumor necrosis factor alpha and interleukin-6 in the acupuncture group were significantly lower than those in the model group (P < 0.05). (5) In conclusion, the acupuncture of “Xingnao Kaiqiao” can improve the symptoms and cognitive ability of the immature rat model of cerebral palsy by up-regulating the serum levels of tumor necrosis factor alpha and interleukin-6.中国组织工程研究杂志出版内容重点：肾移植；肝移植；移植；心脏移植；组织移植；皮肤移植；皮瓣移植；血管移植；器官移植；组织工程
|
| 关 键 词： | 实验动物 神经损伤与修复动物模型 醒脑开窍针刺法 脑瘫 幼鼠 行为学 肿瘤坏死因子α 白细胞介素6 |
| 收稿时间： | 2016-09-02 |
Effect of acupuncture of “Xingnao Kaiqiao” on the behavior of an immature rat model of cerebral palsy and the underlying mechanism |
| |
| Lou Yuan-jun,Liu Yang,Shan Hai-jun,Cao Cai-hong,Jie Xiao-su. Effect of acupuncture of “Xingnao Kaiqiao” on the behavior of an immature rat model of cerebral palsy and the underlying mechanism[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(49): 7314-7319. DOI: 10.3969/j.issn.2095-4344.2016.49.003 |
| |
| Authors: | Lou Yuan-jun Liu Yang Shan Hai-jun Cao Cai-hong Jie Xiao-su |
| |
| Affiliation: | 1Department of Children Rehabilitation, Henan Province Hospital of TCM, Zhengzhou 450000, Henan Province, China; 2School of Graduate of Henan University of Chinese Medicine, Zhengzhou 450000, Henan Province, China |
| |
| Abstract: | ![]()
|
| |
| Keywords: | Cerebral Palsy Acupuncture Tumor Necrosis Factor-alpha Interleukin-6 Tissue Engineering |
|
| 点击此处可从《中国组织工程研究》浏览原始摘要信息 |
|
点击此处可从《中国组织工程研究》下载全文 |
|
