| 烧伤病房金黄色葡萄球菌分离株的分子分型及其耐药性 |
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| 引用本文： | 刘玉强,王 黎,李晓玲,刘正祥,袁文常. 烧伤病房金黄色葡萄球菌分离株的分子分型及其耐药性[J]. 中国组织工程研究, 2016, 20(37): 5567-5572. DOI: 10.3969/j.issn.2095-4344.2016.37.014 |
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| 作者姓名： | 刘玉强 王 黎 李晓玲 刘正祥 袁文常 |
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| 作者单位： | 1解放军第二七三医院传染结核科，新疆维吾尔自治区库尔勒市 841000；2解放军兰州军区乌鲁木齐总医院检验科，新疆维吾尔自治区乌鲁木齐市 830000 |
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| 基金项目： | 国家自然科学基金(81401703) |
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| 摘 要： |
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| 关 键 词： | 组织构建 组织工程 烧伤 耐甲氧西林金黄色葡萄球菌 分子分型 耐药性 国家自然科学基金 |
Molecular typing and antimicrobial susceptibility of Staphylococcus aureus isolates from a burn ward |
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| Liu Yu-qiang,Wang Li,Li Xiao-ling,Liu Zheng-xiang,Yuan Wen-chang. Molecular typing and antimicrobial susceptibility of Staphylococcus aureus isolates from a burn ward[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(37): 5567-5572. DOI: 10.3969/j.issn.2095-4344.2016.37.014 |
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| Authors: | Liu Yu-qiang Wang Li Li Xiao-ling Liu Zheng-xiang Yuan Wen-chang |
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| Affiliation: | 1Department of Infectious Disease & Tuberculosis, the 273rd Hospital of Chinese PLA, Korla 841000, Xinjiang Uygur Autonomous Region, China; 2Clinical Laboratory Diagnostic Center, Urumqi General Hospital of Lanzhou Military Region of Chinese PLA, Urumqi 830000, Xinjiang Uygur Autonomous Region, China |
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| Abstract: | BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) infection had been a global problem up to 1980s, and it has become a leading pathogen giving rise to nosocomial infections now.OBJECTIVE: To determine the molecular types and drug susceptibilities of Staphylococcus aureus prevailed in burn ward, and to provide a basis for preventing and controlling MRSA intections.METHODS: A total of 53 Staphylococcus aureus strains were collected from the burn ward in the Urumqi General Hospital of Lanzhou Military Region of Chinese PLA. These MRSA strains were identified by PCR and cefoxitin disc diffusion test, and all MRSA strains were typed by spa, SCCmec and MLST typing. In the meanwhile, antibiotic susceptibilities of 17 kinds of drugs, such as oxacillin, to Staphylococcus aureus were also determined, and drug resistance of different types of Staphylococcus aureus especially MRSA, was analyzed.RESULTS AND CONCLUSION:Among 53 Staphylococcus aureus strains, 43 were identified as MRSA, containing determined for amplification of meoA (n=41) and positive for cefoxitin disc diffusion test (n=2). Three SCCmec types, four spa types, and three ST types were found. The major predominant clone was ST239-MRSA-III-t030 (90.7%), with highest resistant to oxacillin and other nine antibiotics. In conclusion, the higher MRSA isolation rate from the burn ward, and ST239-MRSA-III-t030, as the predominant clone, presents with an outbreak in the burn ward and stronger resistance to many different families of antibiotics. |
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| Keywords: | Burns Staphylococcus aureus Drug Resistance Tissue Engineering |
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