| 骨组织工程中的间质干细胞：成骨活性、免疫特性、促血管化及成骨效应 |
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| 引用本文： | 陈震东,徐房添,高 辉. 骨组织工程中的间质干细胞：成骨活性、免疫特性、促血管化及成骨效应[J]. 中国组织工程研究, 2016, 20(46): 6956-6956. DOI: 10.3969/j.issn.2095-4344.2016.46.016 |
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| 作者姓名： | 陈震东 徐房添 高 辉 |
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| 作者单位： | 1赣南医学院，江西省赣州市 341000；2赣南医学院第一临床医学院，江西省赣州市 341000 |
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| 基金项目： | 国家自然科学基金(8156090191) |
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| 摘 要： | ![]()
BACKGROUND: It is still a challenge to repair bone defects caused by trauma, infection, tumor and congenital diseases. Bone tissue engineering is a promising method for bone defect repair showing important guiding significance in the clinic.OBJECTIVE: To review the progress of proliferation, osteogenic activity, immunogenicity, proangiogensis and in vivo osteogenic effect of mesenchymal stem cells in bone tissue engineering.METHODS: The first author retrieved Wanfang and PubMed datebase for literatures published from 2008 to 2016, using the keywords of “mesenchymal stem cell, tissue engineering, osteogenesis, immune property, angiogenesis” in Chinese and English, respectively. Articles regarding mesenchymal stem cells, tissue engineering, osteogenesis, immune property and angiogenesis were included, and repetitive and dated studies were excluded. Totally 1 772 articles were retrieved initially, and in accordance with inclusion and exclusion criteria, 41 eligible articles were included for review analysis.RESULTS AND CONCLUSION: Bone marrow mesenchymal stem cells and adipose-derived mesenchymal stem cells are extensively applied in bone tissue engineering. Studies have shown that the osteogenic activity of bone marrow mesenchymal stem cells is higher than that of adipose-derived mesenchymal stem cells, but its immune regulation effect is weaker than that of adipose-derived mesenchymal stem cells. Mesenchymal stem cells hold remarkable immune regulation (immunosuppression and immune enhancement) and tissue repair capacity, which can eliminate inflammatory reactions at injured sites, promoting tissue repair. Adipose-derived mesenchymal stem cells cultured under hypoxia environment can secret more angiogenic cytokines generating more vascular structures. Furthermore, increasing proof have confirmed that porous nano-polylactic acid combined with nano-carbon biological material can significantly promote the proliferation and osteogenesis of bone marrow mesenchymal stem cells. Taking its tumorigenesis into consideration, mesenchymal stem cells should be prudently used in the clinic.中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程
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| 关 键 词： | 组织构建 骨组织工程 间质干细胞 增殖 成骨 免疫 血管化 国家自然科学基金 |
| 收稿时间： | 2016-08-24 |
Mesenchymal stem cells in bone tissue engineering: osteogenic activity,immunogenicity, proangiogensis and osteogenesis |
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| Chen Zhen-dong,Xu Fang-tian,Gao Hui. Mesenchymal stem cells in bone tissue engineering: osteogenic activity,immunogenicity, proangiogensis and osteogenesis[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(46): 6956-6956. DOI: 10.3969/j.issn.2095-4344.2016.46.016 |
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| Authors: | Chen Zhen-dong Xu Fang-tian Gao Hui |
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| Affiliation: | 1Gannan Medical University, Ganzhou 341000, Jiangxi Province, China; 2First Clinical Institute of Gannan Medical University, Ganzhou 341000, Jiangxi Province, China |
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| Abstract: | ![]()
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| Keywords: | Mesenchymal Stem Cells Bone and Bones Immunity Tissue Engineering |
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