| 智能水凝胶在骨类硬组织再生和修复中的应用 |
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| 引用本文： | 杨 琳,管晓燕,陈黎明,刘建国. 智能水凝胶在骨类硬组织再生和修复中的应用[J]. 中国组织工程研究, 2016, 20(3): 430-434. DOI: 10.3969/j.issn.2095-4344.2016.03.023 |
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| 作者姓名： | 杨 琳 管晓燕 陈黎明 刘建国 |
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| 作者单位： | 遵义医学院口腔学院，贵州省遵义市 563099；贵州省高等学校口腔疾病研究特色重点实验室，遵义市口腔疾病研究重点实验室，贵州省遵义市 563099；贵阳市口腔医院，贵州省贵阳市 550002 |
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| 基金项目： | 贵州省科技创新人才团队建设项目(黔科合人才团队[2013]4026)；贵州省高等学校重点学科建设项目(SZXK-201207-04号)；贵州省高等学校特色重点实验室建设项目(黔教合KY字[2013]109)；贵州省科技厅联合基金项目(黔科合SY字合J字[2012]47号)和省市科技合作专项资金项目(省市科合[2014]41号) |
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| 摘 要： |
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| 关 键 词： | 生物材料 骨生物材料 水凝胶 分类 矿化能力 骨再生 骨修复 支架 应用 |
Application of intelligent hydrogels in bone regeneration and repair |
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| Yang Ling,Guan Xiao-yan,Chen Li-ming,Liu Jian-guo. Application of intelligent hydrogels in bone regeneration and repair[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(3): 430-434. DOI: 10.3969/j.issn.2095-4344.2016.03.023 |
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| Authors: | Yang Ling Guan Xiao-yan Chen Li-ming Liu Jian-guo |
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| Affiliation: | School of Stomatology, Zunyi Medical University, Zunyi 563099, Guizhou Province, China; the Special Key Laboratory of Oral Diseases Research, Institution of Higher Education in Guizhou Province, the Key Laboratory of Oral Diseases Research of Zunyi City, Zunyi 563099, Guizhou Province, China; Guiyang Stomatological Hospital, Guiyang 550002, Guizhou Province, China |
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| Abstract: | BACKGROUND: Intelligent hydrogel as a new material is widely used in biological medicine, tissue engineering, memory element switch, biological enzyme immobilization and other related fields, and exhibits good biological characteristics. Intelligent hydrogels provide a new approach for regeneration and repair of bone and other hard tissues. OBJECTIVE: To summarize the latest developments of intelligent hydrogel in the biological medicine and tissue engineering in order to find out new methods for regeneration and repair of bone and other hard tissues.METHODS: A computer-based research of CNKI, PubMed and EBSCO-MEDLINE databases was performed to retrieve relevant literatures about the application of intelligent hydrogel in regeneration and repair of bone and other hard tissues published from 2000 to 2015. The keywords were “hydrogel, bone tissue engineering, bone defect, regeneration, repair” in Chinese and English, respectively.RESULTS AND CONCLUSION: Intelligent hydrogels are classified into pH-sensitive, temperature-sensitive, light-sensitive, multiple-sensitive and other sensitive hydrogels. In order to improve the mineralization ability of the hydrogel and construct the three-dimensional polymer scaffold of hydrogel, the main structure of the hydrogel materials can be mixed with various signal factors, thus achieving the multi-utility and multi-function of the material system, which will become the development trend of tissue engineering construction. |
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