| 胰岛素缓释载体材料应用研究与问题 |
| |
| 引用本文： | 陈国昌,高 红. 胰岛素缓释载体材料应用研究与问题[J]. 中国组织工程研究, 2016, 20(30): 4532-4538. DOI: 10.3969/j.issn.2095-4344.2016.30.018 |
| |
| 作者姓名： | 陈国昌 高 红 |
| |
| 作者单位： | 首都医科大学附属北京妇产医院，北京市 100026 |
| |
| 摘 要： |
|
| 关 键 词： | 生物材料 缓释材料 胰岛素 缓释载体 |
| 收稿时间： | 2016-05-16 |
Sustained-release carriers of insulin: applications and existing problems |
| |
| Chen Guo-chang,Gao Hong. Sustained-release carriers of insulin: applications and existing problems[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(30): 4532-4538. DOI: 10.3969/j.issn.2095-4344.2016.30.018 |
| |
| Authors: | Chen Guo-chang Gao Hong |
| |
| Affiliation: | Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China |
| |
| Abstract: | BACKGROUND: Sustained-release carriers of insulin shaped as microspheres made of different biomaterials have become an issue of concern. OBJECTIVE: To summarize the carrier materials and methods to prepare sustained-release microspheres of insulin. METHODS: Wanfang and PubMed databases were retrieved by computer for articles related to sustained-release carriers of insulin published from 1997 to 2015. The search terms were “insulin, controlled-release carrier, biomaterials” in Chinese and English, respectively. RESULTS AND CONCLUSION: Natural biodegradable polymer materials are preferred to prepare sustained-release microspheres of insulin, including gelatin, alginate, chitosan and its derivatives. These natural materials have good biocompatibility, degradability, film-forming and microsphere-forming abilities. Synthetic biodegradable polymer materials as carrier materials can promote drug stability and effective utilization, and realize targeted drug delivery. According to different physicochemical properties of materials, sustained-release carriers of insulin that meet different requirements can be prepared using emulsion-chemical crosslinking, spray drying and solvent evaporation methods. This review provides new insight into the development of stable drug carriers. |
| |
| Keywords: | Insulin Delayed-Action Preparations Tissue Engineering |
|
| 点击此处可从《中国组织工程研究》浏览原始摘要信息 |
|
点击此处可从《中国组织工程研究》下载全文 |
|
