| 组织工程支架材料修复关节软骨缺损 |
| |
| 引用本文： | 方洪松,周建林,彭 昊,邓 爽,翁金清,刘 丰,陈 森,周观金. 组织工程支架材料修复关节软骨缺损[J]. 中国组织工程研究, 2016, 20(52): 7891-7898. DOI: 10.3969/j.issn.2095-4344.2016.52.020 |
| |
| 作者姓名： | 方洪松 周建林 彭 昊 邓 爽 翁金清 刘 丰 陈 森 周观金 |
| |
| 作者单位： | 武汉大学人民医院骨关节外科，湖北省武汉市 430060 |
| |
| 基金项目： | 国家自然科学基金资助项目(81301592) |
| |
| 摘 要： |
|
| 关 键 词： | 生物材料 软骨生物材料 关节软骨 缺损 支架材料 修复 国家自然科学基金 |
| 收稿时间： | 2016-11-02 |
Tissue-engineered scaffolds for articular cartilage repair |
| |
| Fang Hong-song,Zhou Jian-lin,Peng Hao,Deng Shuang,Weng Jin-qing,Liu Feng,Chen Sen,Zhou Guan-jin. Tissue-engineered scaffolds for articular cartilage repair[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(52): 7891-7898. DOI: 10.3969/j.issn.2095-4344.2016.52.020 |
| |
| Authors: | Fang Hong-song Zhou Jian-lin Peng Hao Deng Shuang Weng Jin-qing Liu Feng Chen Sen Zhou Guan-jin |
| |
| Affiliation: | Department of Bone and Joint Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China |
| |
| Abstract: | BACKGROUND: Articular cartilage repair has been a difficulty in the clinical setting, which is mainly treated with autologous or allogeneic osteochondral grafts, and cartilage periosteum or periosteum grafts. However, the limited source, secondary lesion and immunological rejection force some researchers to search for a novel treatment strategy, cartilage tissue engineering, that is of great significance for cartilage regeneration and repair.OBJECTIVE: To investigate the tissue-engineered scaffolds for the repair of articular cartilage defects. METHODS: The first author searched the PubMed and WanFang databases for the articles addressing tissue-engineered cartilage for articular cartilage defects published between 1991 and 2015 using the keywords “articular cartilage defect, scaffold, tissue engineered cartilage” in English and Chinese, respectively. The irrelative and repetitive literatures were excluded.RESULTS AND CONCLUSION: Finally 48 eligible literatures were enrolled based on the inclusion and exclusion criteria. Cartilage tissue engineering possesses the advantages of controllability, little damage to tissue itself, and biological repair of injured cartilage. Tissue-engineered scaffold material is a critical factor in tissue engineering construction; therefore, it should hold biodegradability and histocompatibility. The commonly used scaffold materials include natural macromolecule materials (collagen, silk fibroin and chitosan), and synthetic polymer materials (polylactic acid and tricalcium phosphate). It is necessary to prepare composite scaffolds with high bioactivity integrate advantages of each material. The tissue engineering is bound to be a hotspot in the field of articular cartilage repair. |
| |
| Keywords: | Cartilage Biocompatible Materials Chitosan Collagen Tissue Engineering |
|
| 点击此处可从《中国组织工程研究》浏览原始摘要信息 |
|
点击此处可从《中国组织工程研究》下载全文 |
|
