| 黏蛋白-1和细胞角蛋白-20在食管癌中的表达及意义 |
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| 引用本文： | 金文波,周乃康,郑梦利,祁彦君,马连君. 黏蛋白-1和细胞角蛋白-20在食管癌中的表达及意义[J]. 肿瘤研究与临床, 2011, 23(1): 237-239. DOI: 10.3760/cma.j.issn.1006-9801.2011.04.007 |
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| 作者姓名： | 金文波 周乃康 郑梦利 祁彦君 马连君 |
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| 作者单位： | 解放军第三○九医院胸外科,北京,100091; |
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| 摘 要： | Objective To investigate the expressions and clinical significances of MUC1-mRNA and CK20-mRNA in peripheral blood of esophageal cancer patients.Methods MUC1-mRNA and CK20-mRNA were detected in 53 patients with esophageal cancer,10 patients with esophageal benign tumor and 20 healthy volunteers by RT-PCR technique.Results The expressions of MUC1-mRNA,CK20-mRNA and combining group were 35.85 % (19/53),49.06 % (26/53) and 62.26 % (36/53) in peripheral blood of 53 esophageal cancer patients.In control group,there was no expression of MUC1-mRNA and CK20-mRNA in peripheral blood of 10 patients with benign esophageal disease and 20 healthy volunteers.The positive rate increased by combining test(x2 =11.0228,P ＜0.05).Conclusion MUC1-mRNA and CK20-mRNA might be specific and sensitive markers to detect circulating tumor cells in peripheral blood and their expressions are closely related to TNM stages of the esophageal cancer patients.The combining test might be of high value of the diagnosis of micrometastasis.
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| 关 键 词： | 食管肿瘤 黏蛋白类 角蛋白质类 肿瘤转移 |
Expressions and clinical significances of MUC1-mRNA and CK20-mRNA in esophageal cancer |
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| JIN Wen-bo,ZHOU Nai-kang,ZHENG Meng-li,QI Yan-jun,MA Lion-jun. Expressions and clinical significances of MUC1-mRNA and CK20-mRNA in esophageal cancer[J]. Cancer Research and Clinic, 2011, 23(1): 237-239. DOI: 10.3760/cma.j.issn.1006-9801.2011.04.007 |
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| Authors: | JIN Wen-bo ZHOU Nai-kang ZHENG Meng-li QI Yan-jun MA Lion-jun |
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| Abstract: | |
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| Keywords: | Esophageal neoplasmsMucinsKeratinsNeoplasm metastasis |
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