| 白细胞介素－3对放烧复合伤小鼠造血功能的影响 |
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| 引用本文： | 罗成基,郭朝华,周燕虹,刘昕. 白细胞介素－3对放烧复合伤小鼠造血功能的影响[J]. 中华放射医学与防护杂志, 1996, 0(1) |
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| 作者姓名： | 罗成基 郭朝华 周燕虹 刘昕 |
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| 作者单位： | 第三军医大学防原医学教研室，第三军医大学分子遗传教研室 |
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| 摘 要： | 作者研究了ＩＬ－３对放烧复合伤动物骨髓造血功能的影响。发现３Ｔ３－ＩＬ－３细胞培养上清液中含有很高活性的ＩＬ－３。用它给放射损伤或放烧复合伤动物预防加治疗应用，对造血的刺激作用显著优于单独预防或单独治疗。对造血的这种良好作用既表现在造血实质细胞，也表现在造血基质细胞；在实质细胞中粒系祖细胞、红系早期和晚期祖细胞都有作用。ＩＬ－３对造血功能未表现抑制的烧伤动物未显示出对造血的刺激作用。
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| 关 键 词： | 白细胞介素－3，放烧复合伤，造血功能 |
Effects of interleukin-3 on hemopoietic function after combined radiation-burn injury in mice |
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| Luo Chengji, Guo Chaohua, Zhou Yanhong and Liu Xin. Effects of interleukin-3 on hemopoietic function after combined radiation-burn injury in mice[J]. Chinese Journal of Radiological Medicine and Protection, 1996, 0(1) |
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| Authors: | Luo Chengji Guo Chaohua Zhou Yanhong Liu Xin |
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| Abstract: | Destruction of hemopoietic function is one of the most basic pathologic changes in combined radiation-burn injury. Interleukin-3 exhibits a broad-spectum stimulating effect on proliferation and differentiation for hemopoietic cells. This study was aimed to investigate the effects of interleukin-3 on hmopoietic function after combined radiation-burn injury in mice. The results show that preventing and additionally treating radiation injury or the combined radiation-burn injury with IL-3 have better effects on the stimulation of hematopoiesis in vivo than only preventing or treating with IL-3. This favourable stimulation of hemopoiesis was not only expressed in granulocyte-macrrophage progentors(CFU-GM) or erythroid progenitors(CFU-E, BFU-E), but also in bone marrow stromal elements(CFU-F). Stimulating effect on hemopoiesis was not shown in animals with burn injury in which hemopoietic failures did not appear. The results indicate that excellent prospects are expected by using IL-3 in treating radiation injury or combined radiation-burn injury. |
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| Keywords: | Interleukin-3 combined radiation-burn injury hematopoietic function |
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