Interleukin-15 enhances innate and adaptive immune responses to blood-stage malaria infection in mice |
| |
| Authors: | Ing Rebecca Gros Philippe Stevenson Mary M |
| |
| Affiliation: | Centre for the Study of Host Resistance, Research Institute of the McGill University Health Centre, 1650 Cedar Ave., Montreal, Quebec H3G 1A4, Canada. |
| |
| Abstract: | Compared to C57BL/6 wild-type mice, interleukin-15(-/-) (IL-15(-/-)) mice showed delayed clearance of Plasmodium chabaudi AS infection, lower type 1 cytokine production, impaired dendritic cell and NK cell functions, and lower titers of malaria-specific antibodies. Thus, IL-15 supports early control and timely resolution of blood-stage malaria through promotion of Th1-dependent innate and adaptive immune responses. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
