| 乐脉颗粒对心肌缺血的保护作用及其机制 |
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| 引用本文： | 蔡小军,邵南齐,付金芳,高青,马记平. 乐脉颗粒对心肌缺血的保护作用及其机制[J]. 南京中医药大学学报, 2016, 32(2): 176-180 |
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| 作者姓名： | 蔡小军 邵南齐 付金芳 高青 马记平 |
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| 作者单位： | 1.南京医科大学附属无锡市人民医院药学部，江苏 无锡?214023 |
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| 摘 要： | 目的?探讨乐脉颗粒对大鼠心肌缺血的作用及其机制。方法?48只SD雄性大鼠随机分为正常组、模型组、阳性（稳心颗粒）组、乐脉颗粒高、中、低剂量组(0.84、0.42、0.21?g/kg)。腹腔注射盐酸异丙肾上腺素(ISO)复制大鼠ISO模型，连续灌胃乐脉颗粒7?d后，记录心电图Ⅱ导联ST段，并取血测定血清中CK、LDH、SOD活性及MAD、NO、ET、IL-1β、TNF-α、CRP含量，同时检测血液流变学指标。结果?与模型组比较，乐脉颗粒各组ST段抬高值及CK、LDH活性均降低(P<0.01)；乐脉颗粒高、中剂量组SOD的活性及NO含量均有不同程度的升高，而ET、IL-1β、TNF-α、CRP含量均有不同程度降低(P<0.05~0.01)，血液流变学各项指标显著改善。结论?乐脉颗粒改善心肌缺血的作用可能与抗氧化应激损伤、调节内皮细胞的功能、抗炎及改善血流变有关。
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| 关 键 词： | 乐脉颗粒 心肌缺血 抗氧化 内皮功能 抗炎 血液流变学 |
| 收稿时间： | 2016-01-04 |
| 修稿时间： | 2016-02-02 |
Protective Effects of Lemai Granules on Myocardial Ischemia and Its Mechanisms |
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| CAI Xiao-jun,SHAO Nan-qi,FU Jin-fang,GAO Qing,MA Ji-ping. Protective Effects of Lemai Granules on Myocardial Ischemia and Its Mechanisms[J]. Journal of Nanjing University of Traditional Chinese Medicine(Natural Science), 2016, 32(2): 176-180 |
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| Authors: | CAI Xiao-jun SHAO Nan-qi FU Jin-fang GAO Qing MA Ji-ping |
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| Affiliation: | 1.Department of Pharmacy, Wuxi People's Hospital Affliated to Nanjing Medical University, Wuxi, 214023, China2.Laboratory of Pharmacology and Toxicology, Zhengzhou Shu Qing Medical College, Zhengzhou, 450064, China |
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| Abstract: | OBJECTIVE?To observe the effect of Lemai granules on model rats with myocardial ischemia and explore its mechanism. METHODS?48 male SD rats were randomly divided into six groups: normal group， model group， positive control group （Wenxin granules group）and high， middle and low dose group (0.84， 0.42， 0.21?g/kg) of Lemai granules. Myocardial ischemia rats model was established by intraperitoneal injection of isoproterenol (ISO)， and then different doses of Lemai granules were administered intragastrically to the myocardial ischemia rats for 7?d. The changes of the ST-segment of Ⅱlead electrocardiogram (ECG) was observed. The activities of CK， LDH and SOD， the content of MDA， NO， ET， IL-1β，TNF-α and CRP in serum were measured， and changes of blood rheology were tested. RESULTS?ST-segment and the activities of CK and LDH of Lemai granules groups(0.84?g/kg， 0.42?g/kg， 0.21?g/kg) were lower obviously than that of model group (P<0.01). Compared with the model group， the activities of SOD and NO in Lemai granule groups of the high and middle doses (0.84?g/kg and 0.42?g/kg) increased in various degrees， while the levels of MDA， ET， IL-1β， TNF-α and CRP were decreased (P<0.05~0.01). The blood rheology were improved significantly. CONCLUSION?Lemai granules shows promising protective effects on myocardial ischemia and its mechanism may be related to antioxidant action， regulation of endothelial cells， anti-inflammatory effects and blood rheology improvement. |
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| Keywords: | Lemai granules myocardial ischemia antioxidation endothelial functions anti-inflammation blood rheology |
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