| Effect of Total Saponins of Ginseng Leaves on Immunity in Aged Rats |
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| 引用本文： | Zhang Kejian,Liu Gengtao. Effect of Total Saponins of Ginseng Leaves on Immunity in Aged Rats[J]. 中国结合医学杂志, 1999, 5(1): 50-53. DOI: 10.1007/BF02934191 |
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| 作者姓名： | Zhang Kejian Liu Gengtao |
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| 作者单位： | Zhang Kejian (Beijing Hospital，National Chuter for Clinical inboratories，Beijing 100730)Liu Gengtao (Institute of Materia Medica，Chinese Academy of Medical Sciences) |
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| 摘 要： | Thedefensecapacitysuchasanti--infectionisindeclineduringaging.Thedeclinemaycauserepeatedinfectionbypathogens,andtheinfectioniscloselyrelatedtothedecreaseoflymphocyte--mediatedspecificimmunityandneutrophil--mediatednon--specificimmunity("').Lymphocyteandneutrophiltakethekeyrolesinthehost--defensesystem,suchasthekillingofpathogensandcancercellsandtheeliminationofalienobjects.GinsenghaslongbeenconsideredasatonicintraditionalChinesemedicine.GinsengsaPOninshavebeenstudiedusingmodernpharmacologyan…
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Effect of total saponins of Ginseng leaves on immunity in aged rats |
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| Zhang Kejian and Liu Gengtao. Effect of total saponins of Ginseng leaves on immunity in aged rats[J]. Chinese journal of integrative medicine, 1999, 5(1): 50-53. DOI: 10.1007/BF02934191 |
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| Authors: | Zhang Kejian and Liu Gengtao |
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| Affiliation: | 1. Beijing Hospital, National Center for Clinical Laboratories, 100730, Beijing
2. Institute of Materia Medica, Chinese Academy of Medical Sciences, 100730, Beijing
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| Abstract: | Objective: To explore the effect of total saponins of Ginseng leaves(GS) on the functions ofneutrophil and lymphocyte in the aged rats of 20 months. Methods: Three groups of aged rats were injected intraperiton-eally with doses of 12. 5 mg/kg, 25 kg/mg and 50 mg/kg of GS once daily for 3 days, the declinedimmunity of spleen lymphocytes (proliferation of spleen lymphocyte, phagocytosis), superoxide anion and nitricoxide formation were studied and were compared with those of young rats (2 months). Results: The declinedimmunity of spleen lymphocytes were improved dose-dependently after GS injected. Conclusion: The results indicate that GS may enhance neutrophil and lymphocyte mediated non--specific and specific defense function inaged rats. |
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| Keywords: | ginseng saponins aged rats neutrophils lymphocytes |
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