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Therapeutic Effects of Water-Soluble Echinocandin Compounds on Pneumocystis Pneumonia in Mice |
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| Authors: | Takahisa Furuta Hideyuki Muramatsu Akihiko Fujie Shiro Fujihira Noor Rain Abudullah Somei Kojima |
| Affiliation: | Department of Parasitology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108,1. Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 5-2-3 Tokodai, Tsukuba-shi, Ibaraki, 300-26,2. and Toxicology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 2-1-6 Kashima, Yodogawa-ku, Osaka-shi, Osaka, 532,3. Japan, and Biotechnology Center, Institute for Medical Research, Jalan Pahang 50588, Kuala Lumpur, Malaysia4. |
| Abstract: | The therapeutic effectiveness of water-soluble echinocandin compounds obtained from Coleophoma empetri F-11899, which has a strong inhibitory effect on the growth of fungi, was examined in nude mice with experimental Pneumocystis pneumonia. The studies demonstrated the potential usefulness of the compounds. |
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