| 肠道病毒71型结构蛋白和结构蛋白和非结构蛋白的分子生物学特性 |
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| 引用本文： | 陈姝樾 刘龙丁. 肠道病毒71型结构蛋白和结构蛋白和非结构蛋白的分子生物学特性[J]. 国际生物制品学杂志, 2014, 37(4): 177. DOI: 10.3760/cma.j.issn.1673-4211.2014.006 |
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| 作者姓名： | 陈姝樾 刘龙丁 |
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| 作者单位： | 650031 昆明医科大学基础医学院（陈姝樾）；650118 昆明，中国医学科学院医学生物学研究所云南省重大传染病疫苗研发重点实验室（陈姝樾、刘龙丁） |
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| 摘 要： | 肠道病毒71型（enterovirus 71，EV71）和柯萨奇病毒A组16型感染导致的手足口病已在世界范围内引起数次大规模暴发和流行，成为婴幼儿健康的重大威胁。对EV71结构的分子生物学特征的研究有助于为EV71疫苗的研发提供重要依据，此文就EV71的几种重要结构蛋白和非结构蛋白在病毒感染过程中作用的研究现状做一综述。
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| 关 键 词： | 肠道病毒属 手足口病 病毒结构蛋白质类 病毒非结构蛋白质类 |
Molecular biological characteristics of structural proteins and non-structural proteins of enterovirus 71 |
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| Affiliation: | *School of Basic Medical Science, Kunming Medical University, Kunming 650031, China; *Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Institute of Medical Biology, Chinese Academy of Medicine Science and Peking Union Medical College, Kunming 650118, China |
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| Abstract: | Several large-scale outbreaks and epidemics of hand, foot and mouth disease caused by enterovirus 71 (EV71) and coxsackievirus A16 in the world have become a major threat to infant health. Research on molecular biological characteristics of EV71 structure is fundanmental th the development of EV71 vaccine. This review summarizes the research progress in biological characteristics of structural proteins and non-structural proteins of EV71. |
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| Keywords: | Enterovirus Hand foot and mouth disease Viral structural proteins Viral non-structural proteins |
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