| 血浆转化生长因子β_1与肾功能的相关研究 |
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| 引用本文： | 余海峰,邓晓燕,陈军斌,李春胜,李招云. 血浆转化生长因子β_1与肾功能的相关研究[J]. 实用医学杂志, 2005, 21(17): 1879-1881 |
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| 作者姓名： | 余海峰 邓晓燕 陈军斌 李春胜 李招云 |
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| 作者单位： | 318000,浙江省台州市中心医院肾内科 |
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| 基金项目： | 本课题为浙江省卫生厅立项课题（编号：2003B166） |
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| 摘 要： | 目的:分析血浆转化生长因子β1(TGF-β1)与肾功能间的相关关系。方法:对63例慢性肾功能不全及105例肾功能正常者应用定量酶联免疫吸附试验测定TGF-β1,采用荧光偏振免疫分析法测定同型半胱氨酸,同时测定血清肌酐。结果:肾功能不全组TGF-β1明显高于肾功能正常组犤(6.50±5.89)μg/Lvs(3.88±3.32)μg/L,t=3.82,P=0.000〗。血清肌酐133～339μmol/L组TGF-β1水平最高,血清肌酐≤132μmol/L与血清肌酐≥340μmol/L两组间差异无显著性犤(7.35±6.81)μg/L,(3.88±3.32)μg/L,(4.89±3.56)μg/L,F=11.70,P=0.001〗。结论:血浆TGF-β1与血清肌酐、血红蛋白、同型半胱氨酸相关。TGF-β1可能是导致肾功能损害的重要原因。
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| 关 键 词： | 肾功能不全 慢性 转化生长因子β_1 |
| 收稿时间： | 2005-03-30 |
| 修稿时间： | 2005-03-30 |
The correlation study between plasma transforming growth factor-β1 and renal function |
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| YU Hai-feng,DENG Xiao-yan,CHEN Jun-bin,LI Chun-sheng,LI Zhao-yun. The correlation study between plasma transforming growth factor-β1 and renal function[J]. The Journal of Practical Medicine, 2005, 21(17): 1879-1881 |
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| Authors: | YU Hai-feng DENG Xiao-yan CHEN Jun-bin LI Chun-sheng LI Zhao-yun |
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| Affiliation: | YU Hai-feng,DENG Xiao-yan,CHEN Jun-bin,LI Chun-sheng,LI Zhao-yun. Department of Nephrology,Taizhou Central Hospital,Taizhou 318000,China |
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| Abstract: | Objective To investigate the correlation between plasma transforming growth factor-β1(TGF-β1) and renal function. Methods In 63 patients of chronic renal failure(CRF) and 105 patients of contrast, TGF-β1 was measured with enzyme linked immunosorbent, Homocysteine(Hcy) was measured with fluorescence polarization immunoassay. At time, serum creatinine(SCr) was also measured. Results In CRF group, the level of plasma TGF-β1 was higher than that in the contrast[(6.50±5.89) μg/L vs(3.88±3.32)μg/L,t=3.82,P=0.000]... |
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