| 肺炎支原体23S rRNA突变与患儿临床特征及耐药性的相关性 |
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| 引用本文： | 吴超雄,王爱敏,蔡振荡. 肺炎支原体23S rRNA突变与患儿临床特征及耐药性的相关性[J]. 中华全科医学, 2021, 19(4): 603-606. DOI: 10.16766/j.cnki.issn.1674-4152.001872 |
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| 作者姓名： | 吴超雄 王爱敏 蔡振荡 |
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| 作者单位： | 温州市中西医结合医院儿科，浙江 温州 325000 |
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| 基金项目： | 浙江省中医药科技计划项目(2015ZA237)。 |
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| 摘 要： | 目的 观察肺炎支原体(Mycoplasma pneumoniae,MP)肺炎患儿23S rRNA基因突变特征,探讨该基因突变与患儿临床特征及耐药性的相关性.方法 对2016年1月-2019年1月于温州市中西医结合医院住院治疗的214例小儿肺炎支原体肺炎病例MP菌株进行23S rRNA基因突变检测,并分别纳入无突变组(3...
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| 关 键 词： | 肺炎支原体 23S rRNA 耐药性 基因突变 |
| 收稿时间： | 2020-06-10 |
Correlation between 23S rRNA mutation of Mycoplasma pneumoniae and clinical characteristics and drug resistance in children |
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| WU Chao-xiong,WANG Ai-min,CAI Zhen-dang. Correlation between 23S rRNA mutation of Mycoplasma pneumoniae and clinical characteristics and drug resistance in children[J]. Applied Journal Of General Practice, 2021, 19(4): 603-606. DOI: 10.16766/j.cnki.issn.1674-4152.001872 |
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| Authors: | WU Chao-xiong WANG Ai-min CAI Zhen-dang |
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| Affiliation: | Department of Pediatrics, Wenzhou Integrated Traditional Chinese and Western Medicine Hospital, Wenzhou, Zhejiang 325000, China |
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| Abstract: | Objective This study aimed to observe the mutation characteristics of 23 S rRNA gene in children with Mycoplasma pneumoniae(MP)and explore the correlation amongst the mutation,clinical characteristics and drug resistance in children.Methods A total of 214 cases of infantile MP with 23 S rRNA gene mutation treated with the combination of traditional Chinese and Western medicine in a hospital in Wenzhou from January 2016 to January 2019 were collected and divided into the non-mutated group(36 cases)and mutated group(178 cases).Patient’s general information,clinical data and drug susceptibility test results were collected on the basis of medical records to analyse the correlation between 23 S rRNA gene mutation with the clinical characteristic and drug resistance of the patients.Results A total of 178 cases(83.18%)of 23 S rRNA gene mutations were detected.Compared with the non-mutated group,the proportion of severe pneumonia in the mutated group was higher(83.18%);the mean fever time was longer(7.22±2.13)d;the hospital stay was longer(8.30±3.25)d,and the time to normal body temperature was longer(6.45±2.33)d.The differences were statistically significant(all P<0.05).The drug susceptibility test results showed that the drug resistance rates of azithromycin and roxithromycin in the mutated group(38.20%vs.25.84%)were significantly higher than those in non-mutated group(13.89%vs.8.33%),all P<0.05.Multivariate logistic regression analysis showed that the severity of pneumonia,the time to return to normal body temperature and 23 S rRNA gene mutation were independent related factors of MP resistance(OR=1.693,1.285,3.338,all P<0.05).Conclusion The mutation of A2603 G gene in 23 S rRNA is the main type of MP mutation,which has evident resistance to macrolide antibiotics,which can increase the proportion of children with severe pneumonia and significantly prolong the clinical treatment time of children. |
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| Keywords: | Mycoplasma pneumoniae 23S rRNA Drug resistance Gene mutation |
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