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Multicenter,randomized, controlled trial of S‐1 monotherapy versus S‐1 and interferon‐α combination therapy for hepatocellular carcinoma with extrahepatic metastases
Authors:Hiroaki Nagano  Shuntaro Obi  Etsuro Hatano  Shuichi Kaneko  Fumihiko Kanai  Masao Omata  Akihito Tsuji  Toshiyuki Itamoto  Kazuhide Yamamoto  Masatoshi Tanaka  Shoji Kubo  Koichi Hirata  Hideji Nakamura  Yoshito Tomimaru  Takeharu Yamanaka  Shinsuke Kojima  Morito Monden
Affiliation:1. Department of Surgery, Graduate School of Medicine, Osaka University, Suita, Japan;2. Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Ube, Japan;3. Department of Gastroenterology and Hepatology, Kyoundo Hospital of the Sasaki Institute, Tokyo, Japan;4. Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan;5. Department of Gastroenterology, Kanazawa University Hospital, Kanazawa, Japan;6. Department of Gastroenterology, University of Tokyo, Tokyo, Japan;7. Department of Clinical Oncology, Kochi Health Science Center, Kochi, Japan;8. Department of Surgery, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan;9. Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan;10. Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan;11. Department of Hepato‐Biliary‐Pancreatic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan;12. Department of Surgery, Surgical Oncology & Science, Sapporo Medical University, Sapporo, Japan;13. Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan;14. Department of Biostatistics, Yokohama City University School of Medicine, Yokohama, Japan;15. Translational Research Informatics Center, Foundation for Biomedical Research and Innovation, Kobe, Japan
Abstract:
Keywords:hepatocellular carcinoma  interferon  randomized controlled trial  S‐1
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