Monocyte‐derived dendritic cells enhance protection against secondary influenza challenge by controlling the switch in CD8+ T‐cell immunodominance |
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| Authors: | Jazmina L. G. Cruz Anja Lüdtke Sergio Gómez‐Medina Paula Ruibal Juliana Idoyaga César Muñoz‐Fontela |
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| Affiliation: | 1. Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany;2. Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany;3. German Center for Infection Research (DZIF), Partner Site Hamburg, Hamburg, Germany;4. Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USAThese authors share senior authorship;5. German Center for Infection Research (DZIF), Partner Site Hamburg, Hamburg, GermanyThese authors share senior authorship |
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| Abstract: | Influenza virus infection triggers an increase in the number of monocyte‐derived dendritic cells (moDCs) in the respiratory tract, but the role of these cells during antiviral immunity is still unclear. Here we show that during influenza infection, moDCs dominate the late activation of CD8+ T cells and trigger the switch in immunodominance of the CD8+ T‐cell response from acidic polymerase specificity to nucleoprotein specificity. Abrogation of monocyte recruitment or depletion of moDCs strongly compromised host resistance to secondary influenza challenge. These findings underscore a novel function of moDCs in the antiviral response to influenza virus, and have important implications for vaccine design. |
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| Keywords: | CD8+ T cell · Dendritic cell · Immunodominance · Influenza virus · Monocyte |
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