| 嗅神经母细胞瘤临床分析（附13例） |
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| 引用本文： | 马双双1,' target='_blank'>2,刘剑锋3,滕峰4,游佳1,' target='_blank'>2,鲁翔华1,' target='_blank'>2,李利亚2. 嗅神经母细胞瘤临床分析（附13例）[J]. 现代肿瘤医学, 2020, 0(22): 3868-3872. DOI: 10.3969/j.issn.1672-4992.2020.22.008 |
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| 作者姓名： | 马双双1 ' target='_blank'>2 刘剑锋3 滕峰4 游佳1 ' target='_blank'>2 鲁翔华1 ' target='_blank'>2 李利亚2 |
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| 作者单位： | 1.北京中医药大学,北京 100029;2.中日友好医院中西医结合肿瘤科;3.耳鼻喉科;4.放射肿瘤科,北京 100029 |
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| 基金项目： | National Natural Science Foundation of China(No.30801281,81870699）;国家自然科学基金（编号:30801281,81870699） |
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| 摘 要： | 目的:总结嗅神经母细胞瘤患者的临床资料,探讨其临床特征、治疗方法及预后。方法:回顾性分析了中日友好医院2011年1月至2019年12月收治的13例嗅神经母细胞瘤患者临床资料,采用SPSS statistics 25软件统计分析患者的年龄、临床症状、改良Kadish分期、治疗方式与预后的关系,比较不同治疗方案的疗效。结果:年龄＞60岁和晚期（C/D期）的患者平均生存时间较短,术后放疗可提高患者生存率（P=0.003）,接受不同的治疗方法生存率比较差异有统计学意义（P=0.010）。结论:嗅神经母细胞瘤多以单侧鼻塞、头痛、嗅觉障碍、鼻出血等为首发症状,易出现复发和转移,以手术+放疗±化疗+中药为主的综合治疗是较优的治疗方案,应注重对患者的长期随访。
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| 关 键 词： | 嗅神经母细胞瘤 治疗方式 中医药 预后 |
Clinical analysis of 13 cases of olfactory neuroblastoma |
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| MA Shuangshuang,' target='_blank'>,LIU Jianfeng,TENG Feng,YOU Jia,' target='_blank'>,LU Xianghua,' target='_blank'>,LI Liya. Clinical analysis of 13 cases of olfactory neuroblastoma[J]. Journal of Modern Oncology, 2020, 0(22): 3868-3872. DOI: 10.3969/j.issn.1672-4992.2020.22.008 |
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| Authors: | MA Shuangshuang ' target='_blank'> LIU Jianfeng TENG Feng YOU Jia ' target='_blank'> LU Xianghua ' target='_blank'> LI Liya |
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| Affiliation: | 1.Beijing University of Chinese Medicine,Beijing 100029,China;2.Department of Oncology,Integrated Traditional Chinese and Western Medicine;3.Department of Otolaryngology;4Department of Radiation Oncology,China-Japan Friendship Hospital,Beijing 100029,China. |
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| Abstract: | Objective:To summarize the clinical data of patients with olfactory neuroblastoma,to explore its clinical features,treatment modality and prognosis.Methods:The clinical data of thirteen cases diagnosed as olfactory neuroblastoma and underwent treatments in China－Japan Friendship Hospital during the period from January 2011 to December 2019 were retrospectively analysed.Statistical analysis was performed to search for relationships between age,clinlcal symptom,Kadish stage,treatment modalities and prognosis by SPSS statistics 25 software.Results:The average survival time of age>60 years old and late Kadish stage(C/D) patients was short.Postoperative radiotherapy can improve survival rate(P=0.003).There were statistically significant differences in survival rates among different treatment modalities(P=0.010).Conclusion:The most common symptom of olfactory neuroblastoma is unilateral nasal obstruction,headache,recurrent epistaxis,olfactory dysfunction.It is prone to recurrence and metastasis.Attention should be paid to the long-term follow-up of patients.A comprehensive treatment(surgery+radiotherapy±chemotherapy+traditional Chinese medicine) is a better treatment modality. |
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| Keywords: | olfactory neuroblastoma treatment modality traditional Chinese medicine prognosis |
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