| TLR4调控自噬与肾脏疾病的研究进展 |
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| 引用本文： | 易扬,谢恺庆. TLR4调控自噬与肾脏疾病的研究进展[J]. 天津医药, 2020, 48(3): 231-236. DOI: 10.11958/20193078 |
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| 作者姓名： | 易扬 谢恺庆 |
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| 作者单位： | 广西医科大学第二附属医院肾内科（邮编 530008） |
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| 摘 要： | 自噬是一种高度保守的分解过程,用于清除细胞质组分,包括蛋白质聚集物和受损的细胞器。自噬的作用不仅有降解产物,而且它也是一个动态的回收系统,为细胞修复和动态平衡产生新的蛋白和能量。近年来研究表明 Toll 样受体 4（TLR4）作为介导病原体识别和免疫活化的受体蛋白诱发相关炎症产生的同时也可介导自噬异常,而自噬异常参与多种肾脏疾病的发生发展。本文从 TLR4 介导自噬异常与肾脏疾病的研究进展进行综述。
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| 关 键 词： | 自噬 肾脏疾病 Toll 样受体 4 炎症 |
| 收稿时间： | 2019-10-16 |
| 修稿时间： | 2019-11-29 |
Advances in Toll-like receptor 4-modulated autophagy and renal disease |
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| YI Yang,XIE Kai-qing. Advances in Toll-like receptor 4-modulated autophagy and renal disease[J]. Tianjin Medical Journal, 2020, 48(3): 231-236. DOI: 10.11958/20193078 |
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| Authors: | YI Yang XIE Kai-qing |
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| Affiliation: | Department of Nephrology, the Second Hospital of Guangxi Medical University, Nanning 530008, China |
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| Abstract: | Autophagy is a highly conserved decomposition process that contributes to the removal of cytoplasmiccomponents, including protein aggregates and damaged organelles. Autophagy not only degrades products, but also is a dynamic recovery system that produces new proteins and energy for cell repairment and homeostasis. Recent studies have shown that Toll-like receptor 4 (TLR4) that mediates pathogen recognition and immune activation receptor protein can induce inflammation and regulate autophagy. The abnormal autophagy is involved in the occurrence and development of various kidney diseases. This article reviews the recent studies of TLR4-mediated autophagy and kidney diseases. |
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| Keywords: | autophagy kidney disease Toll-like receptor 4 inflammation |
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