| 胃癌DWI ADC值与HER-2、CEA表达的相关性分析 |
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| 引用本文： | 王 姣1,' target='_blank'>2,次旦旺久2,卢海燕2,王凤丹2,' target='_blank'>3,罗含欢2. 胃癌DWI ADC值与HER-2、CEA表达的相关性分析[J]. 现代肿瘤医学, 2020, 0(21): 3749-3752. DOI: 10.3969/j.issn.1672-4992.2020.21.024 |
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| 作者姓名： | 王 姣1 ' target='_blank'>2 次旦旺久2 卢海燕2 王凤丹2 ' target='_blank'>3 罗含欢2 |
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| 作者单位： | 1.西藏大学，西藏 拉萨 850000;2.西藏自治区人民医院，西藏 拉萨 850000;3.北京协和医院，北京 100730 |
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| 基金项目： | 西藏自治区自然科学基金（编号:XZ2018ZRG-111） |
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| 摘 要： | 目的:探讨藏族胃癌患者磁共振扩散加权成像（DWI）表观扩散系数（ADC）值与胃癌组织HER-2、CEA表达的相关性。方法:前瞻性研究30例藏族胃癌患者的术前上腹部MRI常规序列+DWI（b=0、1 000 s/mm2）扫描图像，测定胃癌病灶的ADC值。采用免疫组织化学二步法测定HER-2和CEA的表达情况，应用t检验、Spearman秩相关分析、ROC曲线对ADC值、HER-2和CEA进行统计学分析。结果:ADC值在不同HER-2和CEA表达状态中差异均有统计学意义（P<0.05）。病灶ADC值与HER-2高低表达状态存在负相关性（rs=-0.422，P=0.020）；病灶ADC值与CEA表达间亦存在负相关性（rs=-0.403，P=0.027）。鉴别HER-2、CEA不同表达状态的最佳ADC阈值分别为0.925×10-3 mm２/s、0.972×10-3 mm2/s。结论:DWI ADC值有望成为协助临床评估胃癌组织HER-2、CEA表达的指标之一。
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| 关 键 词： | 胃癌 扩散加权成像 表观扩散系数 HER-2 CEA |
Correlation analysis between apparent diffusion coefficient of diffusion-weighted imaging and expression of HER-2 and CEA in gastric cancer |
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| WANG Jiao1,' target='_blank'>2,Cidanwangjiu2,LU Haiyan2,WANG Fengdan2,' target='_blank'>3,LUO Hanhuan2. Correlation analysis between apparent diffusion coefficient of diffusion-weighted imaging and expression of HER-2 and CEA in gastric cancer[J]. Journal of Modern Oncology, 2020, 0(21): 3749-3752. DOI: 10.3969/j.issn.1672-4992.2020.21.024 |
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| Authors: | WANG Jiao1 ' target='_blank'>2 Cidanwangjiu2 LU Haiyan2 WANG Fengdan2 ' target='_blank'>3 LUO Hanhuan2 |
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| Affiliation: | 1.Tibet University，Tibet Lhasa 850000，China；2.Tibet Autonomous Region People's Hospital，Tibet Lhasa 850000，China；3.Peking Union Medical College Hospital，Beijing 100730，China. |
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| Abstract: | Objective:To investigate the correlation between the apparent diffusion coefficient(ADC) of diffusion-weighted imaging(DWI) and the expression of HER-2 and CEA in Tibetan patients with gastric cancer.Methods:The preoperative routine abdominal MRI scan and DWI(b=0，1 000 s/mm2) scan images of 30 Tibetan gastric cancer patients were prospectively analysed.The ADC value of the lesion on DWI images was measured.The expression of HER-2 and CEA was determined by immunohistochemical two-step method.The t-test，Spearman rank correlation analysis and ROC curve were used to analyze the ADC value，HER-2 and CEA.Results:ADC values were statistically different in different HER-2 and CEA expression states(P<0.05).There was a negative correlation between the ADC value of the lesion and the high-low espression status of HER-2(rs=-0.422，P=0.020).There was also a negative correlation between the ADC value of the lesion and CEA expression (rs=-0.403，P=0.027).The optimal ADC thresholds for different expression states of HER-2 and CEA were 0.925×10-3 mm2/s and 0.972×10-3 mm2/s respectively.Conclusion:ADC value of DWI is expected to be one of the indicators to assist clinicians to evaluate the expression of HER-2 and CEA in gastric cancer. |
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| Keywords: | gastric cancer diffusion weighted imaging apparent diffusion coefficient HER-2 CEA |
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