| 肿瘤微环境与免疫治疗耐药的关系及应对 |
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| 引用本文： | 赵 喆,白 桦,王志杰,段建春,王 洁. 肿瘤微环境与免疫治疗耐药的关系及应对[J]. 现代肿瘤医学, 2020, 0(22): 3985-3989. DOI: DOI:10.3969/j.issn.1672-4992.2020.22.033 |
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| 作者姓名： | 赵 喆 白 桦 王志杰 段建春 王 洁 |
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| 作者单位： | 国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院内科，北京 100021 |
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| 基金项目： | 国家重点研发计划（编号:2019YFC1315700）；National Natural Science Foundation of China(No.81630071）；国家自然科学基金会重点项目（编号:81630071）；CAMS医学科学创新基金（编号:CIFMS 2016-I2M-3-008）；教育部创新团队发展项目（编号:IRT-17R10）；Aiyou基金（编号:KY201701）；CAMS肺癌转化研究重点实验室（编号:2018PT31035） |
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| 摘 要： | 免疫治疗的革命性进展开创了肿瘤精准化治疗的新时代，为肿瘤患者带来了长期生存获益。然而，在临床实践中仍存在免疫治疗耐药等诸多挑战。肿瘤微环境（tumor microenvironment,TME）的动态抑制性变化、异质性等特点在肿瘤发生发展、恶性进展、免疫逃逸和治疗耐药中发挥重要作用。因此，了解免疫治疗与TME之间的相互作用不仅对剖析其作用机制至关重要，而且有助于为提高免疫治疗疗效提供新的途径。本综述就TME的起源、动态抑制性变化、异质性特点进行总结，介绍关于TME如何影响免疫疗效的研究进展，以期通过靶向TME角度或联合治疗方式寻求优化免疫治疗疗效的应对策略。
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| 关 键 词： | 肿瘤微环境 抑制性 异质性 免疫逃逸 免疫治疗 |
Coping strategies for the relationship between tumor microenvironment and immunotherapy resistance |
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| ZHAO Zhe,BAI Hua,WANG Zhijie,DUAN Jianchun,WANG Jie. Coping strategies for the relationship between tumor microenvironment and immunotherapy resistance[J]. Journal of Modern Oncology, 2020, 0(22): 3985-3989. DOI: DOI:10.3969/j.issn.1672-4992.2020.22.033 |
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| Authors: | ZHAO Zhe BAI Hua WANG Zhijie DUAN Jianchun WANG Jie |
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| Affiliation: | Department of Medical Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China. |
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| Abstract: | Revolutionary progresses of immunotherapy have ushered in new precision era of cancer treatment,which greatly bring long-term survival benefits for patients.However,there are still many challenges in clinical practices,such as immunotherapy resistance.The characteristics of tumor microenvironment (TME) with dynamic inhibitory changes and heterogeneity play an important role in tumorigenesis and development,malignant progression,immune escape and treatment resistance.Therefore,understanding the interactions between immunotherapy and the TME is not only critical to dissect the mechanisms of action but also beneficial to provide new approaches in improving the efficiency of immunotherapies.In this review,we will summary the origin,dynamic inhibitory changes,and heterogeneous characteristics of TME,and introduce recent work on how the TME can influence the efficacy of immunotherapy,with a view to seeking strategies to optimize the efficacy of immunotherapy through targeting TME perspective or combination therapy. |
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| Keywords: | tumor microenvironment inhibitory heterogeneity immune escape immunotherapy |
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