| Tim-3调控巨噬细胞极化在类风湿性关节炎中的研究进展 |
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| 引用本文： | 钟玉梅,陈洋,罗小超,周海燕. Tim-3调控巨噬细胞极化在类风湿性关节炎中的研究进展[J]. 天津医药, 2020, 48(9): 898-902. DOI: 10.11958/20200625 |
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| 作者姓名： | 钟玉梅 陈洋 罗小超 周海燕 |
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| 作者单位： | 成都中医药大学针灸推拿学院（邮编610075） |
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| 基金项目： | 国家重点研发计划资助项目（2019YFC1709001）；国家自然科学基金面上资助项目（81973959，81674068）；四川省中医药管理局基础研究项目（2018JC007） |
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| 摘 要： | 类风湿性关节炎(RA)是由自身免疫功能紊乱导致的慢性难治性疾病,T细胞被持续活化并长期处于高反应的状态是其免疫反应的重要环节。T细胞免疫球蛋白黏蛋白分子-3(Tim-3)是在免疫系统的各种类型细胞上表达的表面分子,其信号传导可以增强或抑制巨噬细胞的免疫反应。越来越多的研究表明,Tim-3在免疫系统中具有关键作用,可调控巨噬细胞极化,促进各种细胞内信号传导和免疫反应,在RA病理过程中具有重要意义。本文综述近年来关于Tim-3调控巨噬细胞极化在RA中的相关研究进展,为治疗RA提供新的思路。
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| 关 键 词： | 关节炎,类风湿 巨噬细胞 Tim-3 巨噬细胞极化 |
| 收稿时间： | 2020-03-23 |
| 修稿时间： | 2020-06-24 |
Research progress of Tim-3 regulating the polarization of macrophage in rheumatoid arthritis |
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| ZHONG Yu-mei,CHEN Yang,LUO Xiao-chao,ZHOU Hai-yan. Research progress of Tim-3 regulating the polarization of macrophage in rheumatoid arthritis[J]. Tianjin Medical Journal, 2020, 48(9): 898-902. DOI: 10.11958/20200625 |
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| Authors: | ZHONG Yu-mei CHEN Yang LUO Xiao-chao ZHOU Hai-yan |
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| Affiliation: | School of Acupuncture-Moxibustion and Tuina, Chengdu University of TCM, Chengdu 610075, China |
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| Abstract: | Abstract: Rheumatoid arthritis (RA) is a chronic and refractory disease caused by autoimmune dysfunction. The continuous activation and the status of long-term high response of T cells are important links of its immune response. T cell immunoglobulin and mucin-domain-containing molecule-3 (Tim-3) is a surface molecule expressed on various cell types of immune system, and its signal transduction can enhance or inhibit the immune response of macrophages. A large number of studies have indicated that Tim-3 plays an important role in the immune system, such as regulating the polarization of macrophage, promoting the transduction of various intracellular signal and immune responses and playing a key role in the pathogenesis of RA. Therefore, the paper reviews the relevant research progress on Tim-3 regulating the polarization of macrophage in RA in recent years and provides new ideas for deepening the treatment of RA. |
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| Keywords: | arthritis rheumatoid macrophages Tim-3 macrophage polarization |
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