| 影响乳腺癌新辅助化疗后病理完全缓解的临床因素分析 |
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| 引用本文： | 卢宇博,李咸君,张国强. 影响乳腺癌新辅助化疗后病理完全缓解的临床因素分析[J]. 现代肿瘤医学, 2020, 0(21): 3737-3740. DOI: 10.3969/j.issn.1672-4992.2020.21.021 |
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| 作者姓名： | 卢宇博 李咸君 张国强 |
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| 作者单位： | 哈尔滨医科大学附属第三医院乳腺外科，黑龙江 哈尔滨 150000 |
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| 摘 要： | 目的:探讨影响乳腺癌新辅助化疗后病理完全缓解（pathological complete response，pCR）的临床因素。方法:回顾分析新辅助化疗并行根治性手术的120例女性乳腺癌患者的临床资料；所有患者均接受6~8周期EC-T方案化疗，化疗结束后2~4周行根治性手术。采用χ2检验及 Logistic 回归分析影响pCR和非pCR的临床因素。结果:疗效结果单因素分析显示:T分期、N分期、乳腺癌分子分型、治疗前Ki-67表达水平、治疗前血小板水平与乳腺癌新辅助化疗后肿瘤pCR率显著相关。Logistic二元回归分析发现乳腺癌非Luminal分子亚型和新辅助化疗前高血小板水平是影响乳腺癌新辅助化疗后pCR的独立预测因素。结论:乳腺癌非Luminal分子亚型和新辅助化疗前高血小板水平是影响乳腺癌新辅助化疗后pCR的决定性因素。
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| 关 键 词： | 乳腺癌 新辅助化疗 病理完全缓解 |
Analysis of clinical factors influencing pCR of neoadjuvant chemotherapy for breast cancer |
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| LU Yubo,LI Xianjun,ZHANG Guoqiang. Analysis of clinical factors influencing pCR of neoadjuvant chemotherapy for breast cancer[J]. Journal of Modern Oncology, 2020, 0(21): 3737-3740. DOI: 10.3969/j.issn.1672-4992.2020.21.021 |
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| Authors: | LU Yubo LI Xianjun ZHANG Guoqiang |
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| Affiliation: | Department of Breast Surgery，the Third Affiliated Hospital of Harbin Medical University，Heilongjiang Harbin 150000，China. |
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| Abstract: | Objective:To explore the clinical factors affecting pathological complete response after neoadjuvant chemotherapy for breast cancer.Methods:We retrospectively analyzed the clinical data of 120 breast cancer patients who had undergone neoadjuvant chemotherapy combined with radical surgery.All patients received Epirubicin and Cyclophosphomide follow Docetaxel(EC-T) drugs for 6~8 periods，and underwent radical surgery 2~4 weeks after the end of chemotherapy.The clinical factors affecting pCR and non-pCR were analyzed by χ2 test and Logistic regression.Results:Univariate analysis of efficacy results showed that T stage，N stage，breast cancer molecular typing，Ki-67 expression level before treatment，pre-treatment platelet level were significantly correlated with the tumor pCR rate after neoadjuvant chemotherapy for breast cancer.Logistic binary regression analysis found that non-Luminal molecular subtypes of breast cancer and high platelet levels before neoadjuvant chemotherapy were independent predictors of the pCR after neoadjuvant chemotherapy for breast cancer.Conclusion:Non-Luminal molecular subtypes of breast cancer and high platelet levels before neoadjuvant chemotherapy are decisive factors affecting the pCR after neoadjuvant chemotherapy for breast cancer. |
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| Keywords: | breast cancer neoadjuvant chemotherapy pathogical complete response |
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