| 非高危人群的肺癌筛查策略 |
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| 引用本文： | 周耀东,陈宗炜,陈海泉. 非高危人群的肺癌筛查策略[J]. 中国癌症杂志, 2020, 30(10): 726-732. DOI: 10.19401/j.cnki.1007-3639.2020.10.002 |
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| 作者姓名： | 周耀东 陈宗炜 陈海泉 |
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| 作者单位： | 1. 复旦大学附属肿瘤医院胸外科,复旦大学上海医学院肿瘤学系,上海 200032 ;2. 基因工程重点实验室,上海 200032 ;3. 复旦大学胸部肿瘤研究所,上海 200032 ;4. 复旦大学附属中山医院胸外科,上海 200032 |
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| 基金项目： | 国家自然科学基金（81930073,81902310）;上海市科技重大专项（2017SHZDZX01,VBH1323001/026）;上海市临床重点专科项目（SHSLCZDZK02104）;复旦大学先导项目（IDF159034）。 |
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| 摘 要： | 低剂量螺旋计算机断层扫描（low-dose spiral computed tomography,LDCT）筛查肺癌可以将高危人群的死亡率降低20.0％。但是现行的高危人群筛查标准存在局限性,并不能覆盖非高危人群,因此需要有新的具体的筛查策略应对非高危人群的肺癌筛查。现在有些单位把肺癌CT筛查当作员工福利,不分年龄、基线CT结果和其他因素,每年都做1次,不但浪费医疗资源,而且对员工的身心健康亦有害。我们建议将第1次基线LDCT的时间提前至30岁附近,并根据基线CT的发现结果,结合不同年龄段和其他危险因素将随访间隔延长2~10年。针对非高危人群应当采取折中的筛查策略,不但能早期发现肺癌,还能减少CT的辐射暴露。
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| 关 键 词： | 低剂量螺旋计算机断层扫描 肺癌 非高危人群 不吸烟者 惰性 |
Lung cancer screening strategy for non-high-risk population |
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| ZHOU Yaodong,CHEN Zongwei,CHEN Haiquan. Lung cancer screening strategy for non-high-risk population[J]. China Oncology, 2020, 30(10): 726-732. DOI: 10.19401/j.cnki.1007-3639.2020.10.002 |
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| Authors: | ZHOU Yaodong CHEN Zongwei CHEN Haiquan |
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| Affiliation: | 1. Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; 2. Key Laboratory of Genetic Engineering, Shanghai 200032, China; 3. Institute of Thoracic Cancer of Fudan University, Shanghai 200032, China; 4. Department of Thoracic Surgery, Zhongshan Hospital Fudan University, Shanghai 200032, China; |
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| Abstract: | Low-dose spiral computed tomography (LDCT) screening for lung cancer reduced mortality in high-risk groups by 20.0%. The current screening criteria for high-risk groups have limitations and cannot be applied to non-high-risk groups. New specific screening strategies are needed. Now some companies put lung cancer CT screening as a benefit, regardless of age and other factors to do once a year, which is not only a waste of medical resources, but also harmful to physical and mental health. It is recommended to advance the time of the first baseline LDCT to near the age of 30 years, and to extend the follow-up interval from 2 to 10 years according to the findings of baseline CT combined with different age groups and other risk factors. A compromise screening strategy should be adopted for non-high-risk groups to detect lung cancer early and reduce CT radiation exposure. |
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| Keywords: | Low-dose spiral computed tomography Lung cancer Non-high-risk population Non-smokers Indolent |
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