| PD-1/PD-L1通路在血液系统疾病中的研究进展 |
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| 引用本文： | 马银娟,潘耀柱. PD-1/PD-L1通路在血液系统疾病中的研究进展[J]. 现代肿瘤医学, 2020, 0(16): 2905-2909. DOI: 10.3969/j.issn.1672-4992.2020.16.038 |
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| 作者姓名： | 马银娟 潘耀柱 |
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| 作者单位： | 中国人民解放军联勤保障部队第940医院血液科，甘肃 兰州 730050 |
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| 基金项目： | National Natural Science Foundation of China（No.81372132）;国家自然科学基金(编号:81372132） |
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| 摘 要： | 程序性死亡细胞受体-1 (PD-1)被提出已经27年有余。自PD-1首次发现以来，陆续发现其配体PD-L1和PD-L2，以及其他检查点受体如TIM-3和LAG-3，逐步阐明了PD-1/PD-L1通路的作用机理，推动了肿瘤免疫疗法的迅速发展。目前针对PD-1/PD-L1通路的药物已经上市，包括Pembrolizumab 、Nivolumab、Atezolizumab、Avelumab、Durvalumab等，它们被广泛应用于黑色素瘤、非小细胞肺癌、晚期肾细胞癌及肝癌等实体肿瘤的治疗中，取得了显著的疗效。血液系统肿瘤作为人类肿瘤的重要组成部分，免疫疗法也成为近年来研究的热点。这篇综述主要介绍PD-1/PD-L1通路在血液系统中的作用机制，并将其近年来在霍奇金淋巴瘤、白血病等血液系统疾病治疗中的研究进展作一综述,为治疗血液系统疾病提供新的思路和必要依据。
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| 关 键 词： | PD-1 PD-L1 淋巴瘤 多发性骨髓瘤 白血病 |
Research update on PD-1/PD-L1 pathway in hematological diseases |
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| Ma Yinjuan,Pan Yaozhu. Research update on PD-1/PD-L1 pathway in hematological diseases[J]. Journal of Modern Oncology, 2020, 0(16): 2905-2909. DOI: 10.3969/j.issn.1672-4992.2020.16.038 |
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| Authors: | Ma Yinjuan Pan Yaozhu |
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| Affiliation: | Department of Hematology，the 940th Hospital of the Joint Logistic Support Force of Chinese People's Liberation Army，Gansu Lanzhou 730050，China. |
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| Abstract: | Programmed death cell receptor-1 (PD-1) has been proposed for more than 27 years.Since the first discovery of PD-1,its ligands PD-L1 and PD-L2,as well as other checkpoint receptors such as TIM-3 and LAG-3,have been found successively.The mechanism of PD-1/PD-L1 pathway has been gradually clarified,which has promoted the rapid development of cancer immunotherapy.At present,drugs targeting the PD-1/PD-L1 pathway have been marketed,including Pembrolizumab,Nivolumab,Atezolizumab,Avelumab,Durvalumab and so on.They are widely applied to the treatment of solid tumors such as melanoma,non-small cell lung cancer,advanced renal cell carcinoma and hepatocellular carcinoma,and have achieved remarkable therapeutic effects.Hematologic tumor is the most important part of human tumor,and immunotherapy has become a focus of research.This artical reviewed the mechanism of PD-1/PD-L1 pathway in the hematologic diseases,and summarized the research progress in the treatment of hematologic diseases such as Hodgkin's lymphoma and leukemia in recent years,in order to provide a new way and necessary basis for treatment of hematologic diseases. |
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| Keywords: | PD-1 PD-L1 lymphoma multiple myeloma leukemia |
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