| EN2在胶质母细胞瘤中的表达及其预后价值 |
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| 引用本文： | 梁若飞,杨彬彬,唐晓平. EN2在胶质母细胞瘤中的表达及其预后价值[J]. 现代肿瘤医学, 2020, 0(16): 2783-2786. DOI: 10.3969/j.issn.1672-4992.2020.16.011 |
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| 作者姓名： | 梁若飞 杨彬彬 唐晓平 |
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| 作者单位： | 川北医学院附属医院神经外科,四川 南充 637000 |
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| 基金项目： | 南充市科学技术和知识产权局资助项目（编号:18SXHZ0347）;川北医学院博士科研启动基金项目（编号:CBY18-QD04） |
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| 摘 要： | 目的:探讨EN2在胶质母细胞瘤中的表达及其预后价值。方法:利用Oncomine 数据库及GEPIA数据库分析EN2 在胶质母细胞瘤组织中的表达情况;检索GEPIA数据库,分析EN2 在胶质母细胞瘤组织中的表达与预后的相关性。结果:在胶质母细胞瘤组织中EN2的mRNA表达显著高于正常对照组(P＜0.05）;EN2的mRNA表达量与胶质母细胞瘤总生存期存在相关性,即低表达EN2的患者预后较好,高表达EN2的患者预后较差(P=0.015)。结论:EN2基因在胶质母细胞瘤组织中呈高表达,其表达水平对预测胶质母细胞瘤患者的预后具有重要意义。
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| 关 键 词： | EN2 胶质母细胞瘤 表达 预后 |
Expression of EN2 and its prognostic significance in glioblastoma |
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| Liang Ruofei,Yang Binbin,Tang Xiaoping. Expression of EN2 and its prognostic significance in glioblastoma[J]. Journal of Modern Oncology, 2020, 0(16): 2783-2786. DOI: 10.3969/j.issn.1672-4992.2020.16.011 |
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| Authors: | Liang Ruofei Yang Binbin Tang Xiaoping |
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| Affiliation: | Department of Neurosurgery,Affiliated Hospital of North Sichuan Medical College,Sichuan Nanchong 637000,China. |
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| Abstract: | Objective:To investigate the expression and prognostic significance of EN2 in glioblastoma.Methods:The expression of EN2 in glioblastoma tissues was measured in Oncomine database and GEPIA．The correlation between EN2 and the survival time of patients with glioblastoma was analyzed by GEPIA.Results:The mRNA expression of EN2 was significantly increased in glioblastoma tissues than normal tissues（P＜0.05).Moreover,increased expression of EN2 was significantly correlated with poor overall prognosis in patients with glioblastoma（P=0.015).Conclusion:EN2 gene shows high expression in glioblastoma tissues,and its expression level has vital significance in predicting the prognosis of glioblastoma． |
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| Keywords: | EN2 glioblastoma expression prognosis |
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