| 复方六月青对肝纤维化大鼠血清学指标影响 |
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| 引用本文： | 张士军, 李勇文, 张志伟, 陈兆霓, 林兴, 黄仁彬. 复方六月青对肝纤维化大鼠血清学指标影响[J]. 中国公共卫生, 2010, 26(11): 1394-1395. DOI: 10.11847/zgggws2010-26-11-24 |
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| 作者姓名： | 张士军 李勇文 张志伟 陈兆霓 林兴 黄仁彬 |
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| 作者单位： | 1.广西医科大学药理学教研室, 南宁530021 |
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| 基金项目： | 广西科学研究与技术开发计划项目，广西研究生教育创新计划资助 |
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| 摘 要： | 目的探讨复方六月青(CLYQ)对肝纤维化大鼠血清学指标影响。方法采用四氯化碳(CCl4)诱导大鼠肝纤维化模型,酶联免疫吸附实验(ELISA)法检测CLYQ对肝纤维化大鼠血清学指标超氧化物歧化酶(SOD)、丙二醛(MDA)、羟脯氨酸(Hyp)、透明质酸(HA)和金属蛋白酶组织抑制因子-1(TIMP-1)的变化。结果与模型对照组比较,高剂量CLYQ组大鼠血清SOD活力(142.59±9.80)U/mL明显升高(P<0.01);高剂量CLYQ组大鼠血清MDA、Hyp、HA和TIMP-1含量分别为(2.28±0.43)nmol/mL、(6.53±0.77)μg/mL、(111.16±23.89)ng/mL和(2180.69±278.02)pg/mL,明显低于对照组(P<0.01);并呈现剂量效应关系。结论 CLYQ通过抑制脂质过氧化和降低胶原合成,发挥抗肝纤维化作用。
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| 关 键 词： | 复方六月青 肝纤维化 酶联免疫吸附实验 |
| 收稿时间： | 2010-04-28 |
Effect of compound Liuyueqing on serological indexes in hepatic fibrosis rats |
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| ZHANG Shi-jun, LI Yong-wen, ZHANG Zhi-wei, . Effect of compound Liuyueqing on serological indexes in hepatic fibrosis rats[J]. Chinese Journal of Public Health, 2010, 26(11): 1394-1395. DOI: 10.11847/zgggws2010-26-11-24 |
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| Authors: | ZHANG Shi-jun LI Yong-wen ZHANG Zhi-wei |
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| Affiliation: | 1.Department of Pharmacology, Guangxi Medical University, Nanning 530021, China |
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| Abstract: | ObjectiveTo study the effect of compound Liuyueqing(CLYQ)on serological indexes in hepatic fibrosis rats.MethodsHepatic fibrosis model of Sprague-Dawley rats were induced by CCl4.The serum superoxide dismutase (SOD),malondialdehyde(MDA),hydroxyproline(Hyp),hyaluronic acid(HA),and tissue inhibitor of metalloproteinase-1 (TIMP-1)were detected with enzyme linked immunoabsorbent assay(ELISA).ResultsCompared with the model control group,the activity of SOD in the serum was increased significantly in all CLYQ groups(P<0.01)and the serological SOD activity was 142.59±9.80 U/mL in the high dose CLYQ group.The contents of MDA,Hyp,HA and TIMP-1 in the serum decreased significantly in all CLYQ groups(P<0.01 or P<0.05).The serological MDA,Hyp,HA and TIMP-1 contents was 2.28±0.43nmol/mL,6.53±0.77μg/mL,111.16±23.89ng/mL,and 2 180.69±278.02 pg/mL in the high dose CLYQ group,respectively,with dose-effect relationship.ConclusionCLYQ can suppress lipid peroxidation and reduce the collagen synthesis.Hence CLYQ has obvious anti-hepatic fibrosis effect. |
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| Keywords: | compound Liuyueqing hepatic fibrosis ELISA |
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