| 载银珊瑚羟基磷灰石的生物相容性评价 |
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| 引用本文： | 赵华福,张余,李剑,王捷,尹庆水. 载银珊瑚羟基磷灰石的生物相容性评价[J]. 广东医学, 2011, 32(5): 552-554 |
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| 作者姓名： | 赵华福 张余 李剑 王捷 尹庆水 |
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| 作者单位： | 广州军区广州总医院
广州军区广州总医院医学实验科 |
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| 基金项目： | 全军医学卫生科研基金，全军医学科学技术研究"十一五"计划项目，广东省重点实验室建设项目 |
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| 摘 要： | 目的 评价负载8×10-5 mol/L银离子后珊瑚羟基磷灰石(CHA)的生物相容性.方法 采用珊瑚羟基磷灰石材料与AgNO3及NaCl复合,经真空冷冻干燥后制备成8×10-5 mol/L Ag+浓度的载银珊瑚羟基磷灰石(Ag-CHA),并对健康成年昆明小白鼠、新西兰大白兔、白化豚鼠进行了全身急性毒性实验、热原实验、溶血...
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| 关 键 词： | 载银珊瑚羟基磷灰石 生物相容性 全身急性毒性实验 热原实验 溶血实验 致敏实验 |
Biocompatibility of silver-loaded coral hydroxyapatite. |
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| ZHAO Hua-fu,ZHANG Yu,LI Jian,WANG Jie,YIN Qing-shui. Biocompatibility of silver-loaded coral hydroxyapatite.[J]. Guangdong Medical Journal, 2011, 32(5): 552-554 |
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| Authors: | ZHAO Hua-fu ZHANG Yu LI Jian WANG Jie YIN Qing-shui |
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| Affiliation: | ZHAO Hua-fu,ZHANG Yu,LI Jian,WANG Jie,YIN Qing-shui.Department of Medical Reasearch,General Hospital of Guangzhou Military Command,Guangzhou,510010,China |
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| Abstract: | Objective To evaluate the biocompatibility of silver-loated coral hydroxyapatite (Ag-CHA) at 8×10-5 mol/L Ag+ concentration. Methods Silver-loaded coral hydroxyapatite (Ag-CHA) at 8×10-5 mol/L Ag+ concentration was prepared by treating with AgNO3 and NaCl solution, followed by vacuum freeze-drying. To access the biocompatibility of Ag-CHA, the systemic acute toxicity test, pyrogen test, hemolysis test and dermal sensitization test were carried out on healthy adult Kunming mice, New Zealand rabbits, and albino guinea pigs. Results In systemic acute toxicity test, the mice did not lose their weight and had no toxic reaction in 72 hours, 8×10-5 mol/L Ag-CHA had no systemic acute toxicity. In pyrogen test, the highest temperature increments of rabbits were 0.2, 0.2 and 0.4℃ respectively. In hemolysis test, the hemolysis rate was 0.64%. In dermal sensitization test, the skin of guinea pigs in experimental group had no erythema and hydroderma. Conclusion Ag-CHA with 8×10-5 mol/L Ag+ concentration had good biocompatibility and had no systemic acute toxicity, no pyrogen, no hematolysis and no allergen. |
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| Keywords: | silver-loaded coral hydroxyapatite biocompatibility systemic acute toxicity test pyrogen test hemolysis test dermal sensitization test |
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