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| 腺苷的抗抑郁作用及其相关研究 | |
| 引用本文： | 王尔茜,左萍萍. 腺苷的抗抑郁作用及其相关研究[J]. 中国康复理论与实践, 2010, 16(4): 332-334 |
| 作者姓名： | 王尔茜 左萍萍 |
| 作者单位： | 中国医学科学院基础医学研究所药理室，北京市 100005。 |
| 基金项目： | 科技部重大新药创制科技专项项目 |
| 摘 要： | 腺苷作为中枢神经系统(CNS)的重要信号分子，它以磷酸化形式(腺苷三磷酸，ATP)与神经递质一起包装在突触囊泡中被释放。弥散于突触间隙的腺苷与其A1、A2、A3三类受体结合，启动G蛋白介导的信号通路，产生广泛、灵活而多变的生物效应。近年发现，腺苷具有一定的抗抑郁疗效，但机理尚未阐明。本文就腺苷及其受体在抗抑郁作用等方面的研究进行综述。 |
| 关 键 词： | 腺苷 腺苷受体 抗抑郁 综述 |
| 收稿时间： | 2010-03-18 |
Advance in Anti-depression of Adenosine(review) |
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| WANG Er-qian,ZUO Ping-ping. Advance in Anti-depression of Adenosine(review)[J]. Chinese Journal of Rehabilitation Theory and Practice, 2010, 16(4): 332-334 | |
| Authors: | WANG Er-qian ZUO Ping-ping |
| Affiliation: | Departmemt of Pharmacology, Institute of Basic Medical Sciences, School of Basic medicine, PUMC & CAMS, Beijing 100005, China |
| Abstract: | Adenosine is an important signaling molecule of the central nervous system (CNS). Adenosine typically released in the phosphorylated form(ATP),together with neurotransmitter,both of which are encapsulated in the synaptic vesicles. Once released into the synaptic space,adenosine molecules will bind to their three categories of receptors,namely A1 receptor (A1R),A2 receptor (A2R),A3 receptor (A3R),and therefore start G protein mediated signaling pathways,resulting in various and extensive biological effects. ... |
| Keywords: | adenosine adenosine receptors anti-depression review |
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