Protective effects of testosterone propionate on reproductive toxicity caused by Endosulfan in male mice |
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| Authors: | Na Wang Ying Xu Xian‐Qing Zhou Yan‐Hua Wu Sheng‐Li Li Xin Qiao Yan‐Bo Li Zhi‐Wei Sun |
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| Affiliation: | 1. Department of Toxicology and Hygienic Chemistry, School of Public Health, Capital Medical University, Beijing, China;2. Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, China;3. Department of Laboratory Animal Science, School of Basic Medical Sciences, Capital Medical University, Beijing, China;4. Department of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing, China |
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| Abstract: | To investigate the protective effect of testosterone propionate (TP) on reproductive toxicity caused by endosulfan in male mice, three group experiments were designed: the control group received 0 and 0, the endosulfan group received 0.8 and 0, and the endosulfan + TP group received 0.8 mg/kg/d endosulfan and 10 mg/kg/d TP, respectively. The results showed that TP significantly prevented the declines of concentration and motility rates in sperm, reduced the rate of sperm abnormalities in epididymis; and antagonized the decreases in spermatogenous cell and sperm numbers in testes induced by endosulfan. TP also decreased the numbers of cavities formed, prevented the decreases of plasma testosterone and androgen receptor (AR) mRNA in testicular tissue, alleviated the increase of LH induced by endosulfan. It is likely that TP relieve the reproductive toxicity by reversing the endosulfan‐induced decreases in testosterone secretion and AR expression that resulted from the alteration of Leydig cell function. © 2014 Wiley Periodicals, Inc. Environ Toxicol 31: 142–153, 2016. |
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| Keywords: | endosulfan reproductive toxicity androgen receptor oxidative damage energy metabolism testosterone propionate |
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