| 陕西汉族PCI术后人群CYP2C19基因多态性分析 |
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| 引用本文： | 白晓丹,赵超,邓小萍,刘琳娜. 陕西汉族PCI术后人群CYP2C19基因多态性分析[J]. 心脏杂志, 2016, 28(4): 439-442 |
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| 作者姓名： | 白晓丹 赵超 邓小萍 刘琳娜 |
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| 作者单位： | (第四军医大学:1.唐都医院药剂科,陕西 西安 710038,2.西京医院药剂科,陕西 西安 710032） |
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| 摘 要： | 目的 描述陕西省汉族PCI术后人群的细胞色素2C19(CYP2C19)基因型分布特征。方法 采用个体化基因诊断芯片技术对1 220例陕西汉族PCI术后人群进行CYP2C19基因分型检测。结果 陕西汉族术后人群中男性野生基因型比例为34.02%（*1*1）,突变杂合子基因型比例为33.61%（*1*2和1*3）,突变纯合子基因型比例为9.43%（*2*2、*2*3和*3*3）。女性野生基因型比例为9.34%（*1*1）,突变杂合子基因型比例为11.23%（*1*2和1*3）,突变纯合子基因型比例为2.38%（*2*2、*2*3和*3*3）。 结论 陕西汉族PCI术后人群CYP2C19基因多态性以野生型纯合子*1*1和突变杂合子*1*2为主。
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| 关 键 词： | 细胞色素2C19 基因多态性 陕西汉族 氯吡格雷 |
| 收稿时间： | 2015-09-20 |
Genetic polymorphism analysis of CYP2C19 in Shaanxi Han population after percutaneous coronary intervention |
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| BAI Xiao-dan;ZHAO Chao;DENG Xiao-ping;LIU Lin-na. Genetic polymorphism analysis of CYP2C19 in Shaanxi Han population after percutaneous coronary intervention[J]. Chinese Heart Journal, 2016, 28(4): 439-442 |
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| Authors: | BAI Xiao-dan ZHAO Chao DENG Xiao-ping LIU Lin-na |
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| Affiliation: | BAI Xiao-dan;ZHAO Chao;DENG Xiao-ping;LIU Lin-na;Department of Pharmacy,Tangdu Hospital,Fourth Military Medical University;Department of Pharmacy,Xijing Hospital,Fourth Military Medical University; |
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| Abstract: | AIM To study the characteristics of CYP2C19 genotype in Shaanxi Han population after percutaneous coronary intervention (PCI) and establish a foundation for individualized treatment. METHODSGenotyping of CYP2C19 in 1 220 Shaanxi Han patients after PCI were determined by gene chip. RESULTSAccording to genotyping results, the frequencies of wild type (WT) *1*1 in Shaanxi Han population were 34.02%, WT *1*2 and *1*3 were 33.61%, and WT *2*2, *2*3 and *3*3 were 9.43% in males. The frequencies of WT *1*1 were 9.34%, WT *1*2 and *1*3 were 11.23%, and WT *2*2, *2*3 and *3*3 were 2.38% in females. CONCLUSIONGenetic polymorphism analysis of CYP2C19 WT *1*1 and *1*2 in Shaanxi Han population after PCI are most frequent. |
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