| GLP-1生物学及基于GLP-1的抗糖尿病药物研究(英文) |
| |
| 引用本文： | 易凡,李栋,马伟志,杜权. GLP-1生物学及基于GLP-1的抗糖尿病药物研究(英文)[J]. 中国药学, 2013, 22(1): 7-27. DOI: 10.5246/jcps.2013.01.001 |
| |
| 作者姓名： | 易凡 李栋 马伟志 杜权 |
| |
| 作者单位： | 北京大学医学部 天然药物及仿生药物国家重点实验室 |
| |
| 基金项目： | The National Key Basic Research Program of China(Grant No. 2011CBA01100) |
| |
| 摘 要： | 在过去的几十年中,环境和生活方式的改变使得2型糖尿病患者的数量急剧增加, 其中一个重要的病理基础是胰岛素分泌缺陷。胰高血糖素样肽1(GLP-1)是一种由肠道细胞产生及分泌的多肽激素, 该激素以葡萄糖浓度依赖性方式促进胰岛β细胞分泌胰岛素, 调节血糖水平。研究表明GLP-1是糖尿病治疗中的一个有效靶点, 药物研发目前主要集中于GLP-1受体激动剂和降解酶抑制剂两个方面。以其强大的生物学活性为基础, GLP-1药物在临床上表现出高效、低副作用的显著优势。在此, 我们对GLP-1生物学和基于GLP-1的抗糖尿病药物研发进行综述。
|
| 关 键 词： | GLP-1 GLP-1受体 糖尿病 肠促胰腺素 |
| 收稿时间： | 2013-01-08 |
GLP-1 biology and GLP-1 based antidiabetic therapy |
| |
| Fan Yi, Dong Li, Weizhi Ma, Quan Du. GLP-1 biology and GLP-1 based antidiabetic therapy[J]. Journal of Chinese Pharmaceutical Sciences, 2013, 22(1): 7-27. DOI: 10.5246/jcps.2013.01.001 |
| |
| Authors: | Fan Yi Dong Li Weizhi Ma Quan Du |
| |
| Affiliation: | *State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China |
| |
| Abstract: | Environmental and lifestyle factors together account for the dramatic increase of type 2 diabetes in the past decades, in which defective insulin secretion emerges as the major culprit. Glucagon-like peptide 1 (GLP-1) is a peptide secreted from the intestine in response to nutrient ingestion, and plays an essential role in the regulation of blood glucose level by stimulating glucoses-dependent insulin secretion. Recently, GLP-1 develops to be a viable therapeutic target for the treatment of type 2 diabetes, by means of GLP-1 receptor agonists and dipeptidyl peptidase-4 inhibitors. Stemmed from its potent physiological activities, GLP-1-based therapies are clinically efficient and safe for both early and late stages of the disease, with low risk of adverse events. In this review, a comprehensive understanding of GLP-1 biology and the recent development of GLP-1-based antidiabetic therapy are summarized. |
| |
| Keywords: | GLP-1 GLP-1 receptor Diabetes Incretin hormones |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《中国药学》浏览原始摘要信息 |
|
点击此处可从《中国药学》下载免费的PDF全文 |
|
