| 289例胰岛素不良反应病例分析 |
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| 引用本文： | 赵珩,李怡,徐厚明,余江毅. 289例胰岛素不良反应病例分析[J]. 药物流行病学杂志, 2013, 0(7): 375-378 |
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| 作者姓名： | 赵珩 李怡 徐厚明 余江毅 |
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| 作者单位： | 南京中医药大学第一临床医学院（南京 210046）；;中国药科大学药学院；;江苏省药品不良反应监测中心；;江苏省中医院。 |
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| 摘 要： | 目的:分析胰岛素不良反应病例发生的特点,为临床合理用药提供参考。方法:从2004年1月～2012年11月江苏省药品不良反应数据库中检索出胰岛素的不良反应病例,采用描述性分析的方法,对药品不良反应累及的系统、怀疑药品的种类等进行统计分析。结果:共检索出符合条件的病例报告表289例,其中男143,女146例。短效、超短效胰岛素,胰岛素类似物不良反应所占比例较大。药品不良反应累及的系统/器官主要有皮肤及其附件损害、代谢和营养障碍、全身性损害。其中283例通过治疗均好转或痊愈,2例病例留有皮下脂肪萎缩后遗症,4例未好转。结论:胰岛素引起的不良反应累及的系统/器官较多,常多个不良反应同时发生,临床上要进行密切的用药监护,关注少见的不良反应,确保用药安全。
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| 关 键 词： | 胰岛素 药品不良反应 安全用药 |
| 修稿时间： | 2013-04-08 |
Clinical Analysis of Adverse Drug Reaction of 289 Cases Caused by Insulin |
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| Zhao Heng,Li Yi,Xu Houming and Yu Jiangyi. Clinical Analysis of Adverse Drug Reaction of 289 Cases Caused by Insulin[J]. Chinese Journal of Pharmacoepidemiology, 2013, 0(7): 375-378 |
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| Authors: | Zhao Heng Li Yi Xu Houming Yu Jiangyi |
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| Affiliation: | 1.The First Clinical Medical College of Nanjing University of Chinese Medicine,Nanjing 210046,China; 2.Department of Clinical Pharmacy of China Pharmaceutical University;3.Center for ADR Monitoring of Jiangsu;4.Jiangsu Province Hospital of Traditional Chinese Medicine |
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| Abstract: | ABSTRACT Objective: To analyze the clinical characteristics of adverse drug reaction cases caused by insulin to provide reasonable advice for clinical use. Methods:The adverse drug reactions cases caused by insulin were retrieved in the database of Center for ADR Monitoring of Jiangsu to analyze the clinical manifestations, systems involved, types of drugs, etc. Results:143 cases of 289 cases involved were male, and 146 were female. The types of the suspected drugs were mostly regular insulin, ultra short acting insulin and insulin analogue. The systems with adverse drug reactions included the skin and its appendages, metabolism and nutrition disorder and systemic damages. 283 cases were healed or improved after therapy, 2 cases had sequela of partial lipodystrophy, and 4 cases were not healed. Conclusion: Adverse drug reactions caused by insulin occurred in more than one system at the same time; and therefore, clinical medicine use should be closely monitored, and attention should be paid to some rare adverse drug reactions to ensure the safe drug use. |
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| Keywords: | Insulin Adverse drug reaction Safety drug use |
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