Effect of Botulinum Toxin A on Proliferation and Apoptosis inthe T47D Breast Cancer Cell Line |
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| Abstract: | The present study was performed to assess the activity of the botulinum toxin A on breast cancer cells. TheT47D cell line was exposed to diverse concentrations of the botulinum toxin A and cell viability and apoptosiswere estimated using MTT and propidium iodine/annexin V methods, respectively. Botulinum toxin A exertedgreater cytotoxic activity in T47D cells in comparison with MCF10A normal cells; this appeared to be viaapoptotic processes caspase-3 and -7. In conclusion, botulinum toxin A induces caspase-3 and -7 dependentapoptotic processes in the T47D breast cancer cell line. |
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| Keywords: | breast cancer botulinum toxin A Apoptosis Caspases |
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