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| 替罗非班治疗颅内动脉瘤介入围手术期支架内血栓的单中心经验 | |
| 引用本文： | 徐伟东,陈如东,厉华,曾令成,杨洪宽,于加省. 替罗非班治疗颅内动脉瘤介入围手术期支架内血栓的单中心经验[J]. 中国卒中杂志, 2021, 16(6): 556-560. DOI: 10.3969/j.issn.1673-5765.2021.06.005 |
| 作者姓名： | 徐伟东 陈如东 厉华 曾令成 杨洪宽 于加省 |
| 作者单位： | 武汉 430030华中科技大学同济医学院附属同济医院神经外科 |
| 基金项目： | 湖北省自然科学基金（2018CFB458） |
| 摘 要： | 目的 探讨应用替罗非班治疗颅内动脉瘤支架辅助栓塞围手术期支架内血栓的有效性及安全性.方法 回顾性分析2018年6月-2020年12月于华中科技大学同济医学院附属同济医院神经外科行支架辅助颅内动脉瘤栓塞术围手术期发生支架内血栓患者的临床资料,评估应用替罗非班对支架辅助颅内动脉瘤栓塞术围手术期血栓的治疗效果,包括血栓是否溶... |
| 关 键 词： | 替罗非班 颅内动脉瘤 支架辅助栓塞 血栓形成 围手术期 |
| 收稿时间： | 2021-02-28 |
Tirofiban for Periprocedural In-stent Thrombosis during Stent-assisted Coiling of Intracranial Aneurysms:A Single Center Experience#br# |
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| XU Wei-Dong,CHEN Ru-Dong,LI Hua,ZENG Ling-Cheng,YANG Hong-Kuan,YU Jia-Sheng. Tirofiban for Periprocedural In-stent Thrombosis during Stent-assisted Coiling of Intracranial Aneurysms:A Single Center Experience#br#[J]. Chinese Journal of Stroke, 2021, 16(6): 556-560. DOI: 10.3969/j.issn.1673-5765.2021.06.005 | |
| Authors: | XU Wei-Dong CHEN Ru-Dong LI Hua ZENG Ling-Cheng YANG Hong-Kuan YU Jia-Sheng |
| Abstract: | Objective To investigate the efficacy and safety of tirofiban in treatment of periprocedural in-stentthrombosis during stent-assisted coiling of intracranial aneurysms.Methods This retrospective analysis enrolled the patients with perioprocedural in-stent thrombosisduring stent-assisted coiling for intracranial aneurysms at Department of Neurosurgery, TongjiHospital, Tongji Medical College, Huazhong University of Science and Technology from June 2018to December 2020. The clinical data of all the patients were analyzed to evaluate the efficacy andsafety of tirofiban for periprocedural thrombosis, and the assessment indexes included the thrombusdissolution rate, periprocedural bleeding and mRS score at discharge.Results Of 177 patients who underwent stent-assisted coil embolization, 12 cases (6.8%) hadperiprocedural thrombotic events, with a median age of 56.5 years and 11 (91.7%) females,including 10 cases (83.3%) with anterior circulation aneurysms and 2 cases (16.7%) with posteriorcirculation aneurysms, all of which were unruptured aneurysms. Laser sculpting stents were used in4 cases (33.3%) and braided stents were used in 8 cases (66.7%). Intraprocedural thrombotic eventsoccurred in 9 cases (85.0%), and postprocedural thrombotic events occurred in 3 cases (15.0%).After the application of tirofiban, the thrombus was successfully dissolved in all 12 patients. Onlyone patient had an intracerebral hemorrhage after using tirofiban, and this patient had a poor prognosis (mRS 4 points) at discharge, and the remaining 11 patients (91.7%) had no complicationand they all had a good prognosis (all mRS 0 point).Conclusions The application of tirofiban is a safe and effective treatment for periprocedural instentthrombosis during stent-assisted coiling of intracranial aneurysms. |
| Keywords: | Tirofiban,Intracranial aneurysm,Stent-assisted embolization,Thrombosis Periprocedural , |
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