| 45岁以上成年人前房容积测量及其在原发性闭角型青光眼筛查中的价值：北京眼病研究 |
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| 引用本文： | 陈长喜 王进达 曹凯 徐亮 王亚星 李建军. 45岁以上成年人前房容积测量及其在原发性闭角型青光眼筛查中的价值：北京眼病研究[J]. 眼科, 2021, 30(4): 259-264. DOI: 10.13281/j.cnki.issn.1004-4469.2021.04.002 |
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| 作者姓名： | 陈长喜 王进达 曹凯 徐亮 王亚星 李建军 |
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| 作者单位： | 首都医科大学附属北京同仁医院 北京同仁眼科中心 北京市眼科研究所 眼科学与视觉科学北京市重点实验室100005 |
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| 基金项目： | 北京市属医学科研院所公益发展改革试点项目（2019-4） |
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| 摘 要： |
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| 关 键 词： | 前房容积 闭角型青光眼 筛查效能 横断面研究 |
| 收稿时间： | 2021-04-12 |
Anterior chamber volume measurement and its value of screening primary angle-closure glaucoma in adults over 45 years old: The Beijing Eye Study |
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| Chen Changxi,Wang Jinda,Cao Kai,Xu Liang,Wang Yaxing,Li Jianjun. Anterior chamber volume measurement and its value of screening primary angle-closure glaucoma in adults over 45 years old: The Beijing Eye Study[J]. Ophthalmology in China, 2021, 30(4): 259-264. DOI: 10.13281/j.cnki.issn.1004-4469.2021.04.002 |
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| Authors: | Chen Changxi Wang Jinda Cao Kai Xu Liang Wang Yaxing Li Jianjun |
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| Affiliation: | Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Key Laboratory of Beijing Ophthalmology and Visual Science, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, China |
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| Abstract: | Objective To study the measurement results of anterior chamber volume (ACV) in adults over 45 years and its screening value for primary angle closure glaucoma (PACG). Design Cross-sectional survey. Participants 3251 subjects in the Beijing Eye Study 2006. Methods Heidelberg anterior segment optical coherence tomography (AS-OCT) was used to measure the subjects' ACV and other anterior segment parameters. The subjects were divided into different groups according to their refractive status and age for analysis. Spearman rank correlation analysis was used to explore the correlation between ACV and other anterior segment parameters. Receiver operating characteristic curve (ROC) was used to evaluate the value of ACV and other anterior segment parameters in PACG screening. Delong's test was used for comparison of multiple ROC curves. Logistic regression was used to explore the influencing factors of PACG. Main Measure Outcomes ACV, area under the ROC curve. Results The average ACV level of subjects over 45 years old was 132.07±32.66 mm3. The average level of ACV in men was 139.77±33.15 mm3, and 126.15±31.00 mm3 in women. The average ACV level of subjects aged 45~54, 55~64, 65~74 and ≥75 years old was 143.23±31.25 mm3, 129.71±32.65 mm3, 123.71±30.56 mm3 and 115.71±28.92 mm3, respectively. The average ACV levels of myopia, hyperopia subjects were 149.86±37.34 mm3 and 113.39±26.84 mm3. For subjects with PACG, the average ACV level was 79.15±13.63 mm3. When screening PACG, the area under the ROC curve of ACV, anterior chamber depth (ACD), 500 μm anterior chamber angle (ACA) is 0.938, 0.937, 0.938, respectively. According to Youden index, the cut-off value of using ACV to screen PACG is 114.90 mm3. Conclusion The average ACV level of people over 45 years old in Beijing area is 132.07±32.66 mm3. ACV gradually decreases with age. ACV of myopia population is larger. The ability of ACV to screen PACG is not weaker than that of ACA and ACD. ACV with lower than 115 mm3 indicates the higher risk of PACG. (Ophthalmol CHN, 2021, 30: 259-264) |
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| Keywords: | anterior chamber volume angle-closure glaucoma screening efficacy cross-sectional study |
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