| 综合干预对肥胖男性青少年血管生成素样蛋白2和血管内皮功能的影响 |
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| 引用本文： | 姚梦,唐东辉,白爽. 综合干预对肥胖男性青少年血管生成素样蛋白2和血管内皮功能的影响[J]. 中国学校卫生, 2021, 42(12): 1888-1891. DOI: 10.16835/j.cnki.1000-9817.2021.12.031 |
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| 作者姓名： | 姚梦 唐东辉 白爽 |
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| 作者单位： | 1.北京师范大学体育与运动学院, 北京 100875 |
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| 基金项目： | 国家自然科学基金项目71874017国家自然科学基金项目81472992 |
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| 摘 要： | 目的 观察运动结合饮食控制的综合干预方案对肥胖男性青少年血管生成素样蛋白2(angiopoietin-likeprotem 2,ANGPTL2)和血管内皮功能的影响,为运动降低肥胖男性青少年心血管疾病风险提供理论依据.方法 选取42名肥胖男性青少年和10名健康男性青少年分别为实验组和对照组,对实验组青少年开展6周运动结...
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| 关 键 词： | 肥胖症 血管生成素2 心血管系统 青少年 男(雄)性 |
| 收稿时间： | 2021-02-04 |
Effect of comprehensive intervention on ANGPTL2 and vascular endothelial function in obese male adolescents |
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| Affiliation: | 1.College of P.E. and Sports Science, Beijing Normal University, Beijing (100875), China |
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| Abstract: | Objective To investigate the effect of a comprehensive exercise intervention program combined with diet control on ANGPTL2 and vascular endothelial function in obese male adolescents, and to provide theoretual basis for exercise to reduce the risk of cardiovascular disease in obese male adolescents. Methods Forty-two obese male adolescents and 10 healthy male adolescents were selected, a comprehensive intervention of 6 weeks of exercise combined with diet control was carried out on obese male adolescents, and changes in morphological function, glucose and lipid metabolism, inflammation level and vascular endothelial function were measured before and after the intervention. Results After 6 weeks of comprehensive intervention, the morphological and functional indicators of obese adolescents were significantly reduced: weight, BMI, waist circumference, waist-to-hip ratio, systolic blood pressure, diastolic blood pressure (P < 0.05); blood lipid levels significantly decreased, including TC, TG and LDL-C (P < 0.05); inflammation levels significantly decreased, including TNF-α and ANGPTL2 (P < 0.05); Vascular endothelial function significantly improved: RHI, NO/ET-1, NO, AI(P < 0.05). Before and after 6 weeks of comprehensive intervention, the ANGPTL2 of obese adolescents was significantly correlated with weight (r=0.37), BMI (r=0.45), RHI (r=-0.46), NO/ET-1 (r=-0.41), NO(r=-0.45), and AI (r=0.33)(P < 0.05). Conclusion The comprehensive intervention can effectively improve the morphological function, blood lipid level and vascular endothelial function of obese male adolescents, and reduce the circulating level of ANGPTL2. ANGPTL2 may be involved in the process of comprehensive intervention to improve the vascular endothelial function of obese adolescents. |
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