| 白头翁皂苷及其单体抗肿瘤作用及机制的研究进展 |
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| 引用本文： | 宋慧慧,向卓,薛淑一,苗青,赵丽艳,李明春. 白头翁皂苷及其单体抗肿瘤作用及机制的研究进展[J]. 中国药学, 2021, 30(5): 381-392. DOI: 10.5246/jcps.2021.05.030 |
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| 作者姓名： | 宋慧慧 向卓 薛淑一 苗青 赵丽艳 李明春 |
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| 摘 要： | 白头翁是我国中医中一味传统的中药材,广泛应用于中医临床.近年来的医学研究发现,从白头翁中提取的天然产物白头翁皂苷及其单体化合物具有多种生物活性,尤其是从中分离得到的三萜类皂苷,具有显著且广谱的抗肿瘤作用,其潜在抗肿瘤分子机制包括抑制肿瘤细胞的生长和增殖、抑制肿瘤细胞的迁移、侵袭和转移、阻滞肿瘤细胞周期、调控癌细胞能量代...
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| 关 键 词： | 白头翁 白头翁皂苷 单体 抗肿瘤作用 分子机制 |
| 收稿时间： | 2020-09-18 |
Advances in anti-tumor effects and mechanisms of Pulsatilla Chinensis saponins and its monomers |
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| Huihui Song,Zhuo Xiang,Shuyi Xue,Qing Miao,Liyan Zhao,Mingchun Li. Advances in anti-tumor effects and mechanisms of Pulsatilla Chinensis saponins and its monomers[J]. Journal of Chinese Pharmaceutical Sciences, 2021, 30(5): 381-392. DOI: 10.5246/jcps.2021.05.030 |
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| Authors: | Huihui Song Zhuo Xiang Shuyi Xue Qing Miao Liyan Zhao Mingchun Li |
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| Abstract: | As a traditional Chinese herbal medicine, Pulsatilla Chinensis (P. Chinensis) is widely used in the clinical practice of traditional Chinese medicine (TCM). Recently, medical research has found that the natural product P. Chinensis saponins and their monomeric compounds extracted from P. Chinensis have a variety of biological activities, especially the triterpenoid saponins, which have significant and broad-spectrum anti-tumor effects. Moreover, its anti-tumor molecular mechanisms include inhibition of the growth and proliferation of tumor cells, repression of the migration, invasion, and metastasis, prevention of tumor cell cycle, regulation of cancer cell energy metabolism, anti-tumor angiogenesis, induction of cancer cell differentiation, apoptosis and autophagy, reversing cancer cell resistance, regulation a variety of related signaling pathways, and improvement of the inflammatory microenvironment of tumor cells. In the present work, we reviewed the related anticancer mechanisms of P. Chinensis saponins and their monomers in different tumors, aiming to provide a theoretical basis for the development and clinical application of new anti-tumor drugs of P. Chinensis saponins and their monomeric compounds. |
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| Keywords: | Pulsatilla Chinensis Pulsatilla Chinensis saponins Monomer Anti-tumor effect Molecular mechanism |
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