| 白族白-汉双语者与汉族非双语者全脑灰质密度差异的研究 |
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| 引用本文： | 晁芳,刘赐融,孙学进,莫茵,解玥,赵建山,田伟. 白族白-汉双语者与汉族非双语者全脑灰质密度差异的研究[J]. 国际放射医学核医学杂志, 2021, 45(7): 421-426. DOI: 10.3760/cma.j.cn121381-202012023-00076 |
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| 作者姓名： | 晁芳 刘赐融 孙学进 莫茵 解玥 赵建山 田伟 |
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| 作者单位： | 1.四川省宜宾市第二人民医院CT/MRI室 644000;2.中国科学院昆明动物研究所灵长类研究室 650223;3.昆明医科大学第一附属医院磁共振室 650031 |
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| 摘 要： | 目的 通过分析白族白-汉双语者与汉族非双语者全脑灰质密度的差异，初步探讨少数民族第二语言习得可能的大脑基础及后天学习对大脑微观结构的影响。 方法 回顾性分析2012年4月至2013年4月于昆明医科大学第一附属医院就诊的33名熟练掌握白族语言和汉语2种语言的白族健康成年人[简称白族白-汉双语者，其中男性18名、女性15名，年龄20~50（25.33±4.65）岁]和30名使用汉语单一语言的汉族健康成年人[简称汉族非双语者，其中男性13名、女性17名，年龄20~50（26.16±2.05）岁]的大脑MRI显像资料。对白族白-汉双语者和汉族非双语者进行三维T1加权扫描，所得数据采用基于体素的形态学分析（VBM）方法分析全脑灰质密度，并采用双样本t检验比较2组受试者全脑灰质密度的差异。 结果 全脑灰质密度差异及其统计参数图的结果显示，白族白-汉双语者的右侧额中回（t=4.00，P<0.001）、右侧眶回（t=2.68，P<0.001）、右侧直回（t=2.25，P<0.001）、左侧直回（t=2.69，P<0.001）、左侧豆状核（t=3.90，P<0.001）局部灰质密度明显高于汉族非双语者。 结论 白族白-汉双语者与汉族非双语者全脑灰质密度有差异的脑区集中在前额叶和纹状体，其与白族白-汉双语者第二语言的习得关系密切，后天第二语言的学习可能导致大脑微观结构的改变。
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| 关 键 词： | 汉族 磁共振成像 白族 白-汉双语 基于体素的形态学分析 灰质密度 |
| 收稿时间： | 2020-12-18 |
Differences in grey matter density of the whole brain between Bai-Han bilinguals and Han non-bilinguals |
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| Fang Chao,Cirong Liu,Xuejin Sun,Yin Mo,Yue Xie,Jianshan Zhao,Wei Tian. Differences in grey matter density of the whole brain between Bai-Han bilinguals and Han non-bilinguals[J]. International Journal of Radiation Medicine and Nuclear Medicine, 2021, 45(7): 421-426. DOI: 10.3760/cma.j.cn121381-202012023-00076 |
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| Authors: | Fang Chao Cirong Liu Xuejin Sun Yin Mo Yue Xie Jianshan Zhao Wei Tian |
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| Affiliation: | 1. Department of CT/MRI, the Second People's Hospital of Yibin City of Sichuan Province, Yibin 644000, China;2. Department of Primate Research, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China;3. Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Kunming Medical University, Kunming 650031, China |
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| Abstract: | Objective To primarily discuss the brain structural underpinnings of learning second language of ethnic minorities and the effects of acquired learning on brain microstructure by analyzing the differences of gray matter density between Bai-Han bilinguals and Han non-bilinguals. Methods A retrospective analysis was performed on brain MRI data collected from 33 healthy Bai adults who were proficient in Bai and Chinese language (hereafter Bai-Han bilinguals, 18 males and 15 females, aged 20–50 (25.33±4.65) years) and 30 healthy Han adults who were proficient in Chinese language only (hereafter Han non-bilinguals, 13 males and 17 females, aged 20–50 (26.16±2.05) years) in the First Affiliated Hospital of Kunming Medical University from April 2012 to April 2013. Bai-Han bilinguals and Han non-bilinguals underwent MRI scanning to collect three-dimensional T1 structural images, which were used to analyze the grey matter density via voxel-based morphometry. Then, the between-group differences of grey matter density were compared through two-sample t test. Results Compared with Han non-bilinguals, Bai-Han bilinguals had significantly higher grey matter density in the right middle frontal gyrus (t=4.00, P<0.001), right orbital gyrus (t=2.68, P<0.001), right straight gyrus (t=2.25, P<0.001), left straight gyrus (t=2.69, P<0.001), and left lenticular nucleus (t=3.90, P<0.001). Conclusion The brain areas with differences in gray matter density between Bai-Han bilinguals and Han non-bilinguals were concentrated in prefrontal cortex and striatum, which were closely correlated with the learning of second language in Bai-Han bilinguals, and acquired learning for second language may give rise to cerebral microstructural alterations. |
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| Keywords: | Han nationality Magnetic resonance imaging Bai nationality Bai-Han bilinguals Voxel based morphometry Grey matter density |
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