| 非动脉炎性前部缺血性视神经病变患者OCTA视盘量化参数及其与病程、视力预后的关系 |
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| 引用本文： | 张秋阳 赵玥 姚进 蒋沁. 非动脉炎性前部缺血性视神经病变患者OCTA视盘量化参数及其与病程、视力预后的关系[J]. 眼科, 2021, 30(6): 425-429. DOI: 10.13281/j.cnki.issn.1004-4469.2021.06.004 |
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| 作者姓名： | 张秋阳 赵玥 姚进 蒋沁 |
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| 作者单位： | 南京医科大学附属眼科医院210029 |
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| 基金项目： | 国家自然科学基金（81870679） |
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| 摘 要： | 目的 应用相干光断层扫描血管成像(OCTA)研究不同病程的非动脉炎性前部缺血性视神经病(NA-AION)的影像特征及视盘量化参数,并探讨其与病程、视力预后之间的关系.设计回顾性病例系列.研究对象2019年1-6月就诊于南京医科大学附属眼科医院的NA-AION患者24例(24眼).方法 回顾分析临床确诊为NA-AION患...
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| 关 键 词： | 非动脉炎性前部缺血性视神经病变 相干光断层扫描血管成像 病程 视力预后 |
| 收稿时间： | 2020-09-20 |
Quantitative optical coherence tomography angiography characteristics and relation with vision and course of disease in non-arteritic anterior ischemic optic neuropathy |
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| Zhang Qiuyang,Zhao Yue,Yao Jin,Jiang Qin. Quantitative optical coherence tomography angiography characteristics and relation with vision and course of disease in non-arteritic anterior ischemic optic neuropathy[J]. Ophthalmology in China, 2021, 30(6): 425-429. DOI: 10.13281/j.cnki.issn.1004-4469.2021.06.004 |
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| Authors: | Zhang Qiuyang Zhao Yue Yao Jin Jiang Qin |
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| Affiliation: | Eye Hospital, Nanjing Medical University, Nanjing 210029, China |
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| Abstract: | Objective To observe the characteristics in non-arteritic anterior ischemic optic neuropathy (NA-AION) using optical coherence tomography angiography (OCTA), and investigate the relation with course of disease and visual prognosis. Design Retrospective case series. Participants 24 eyes (24 cases) of NA-AION in Eye Hospital affiliated to Nanjing Medical University from January to June 2019. Methods At the baseline, one month and six months, comprehensive ophthalmologic examinations were performed, including best corrected visual acuity (BCVA) (LogMAR) and OCTA. The characteristics of (BCVA) (LogMAR) and the average retinal nerve fiber layer (RNFL) thickness and the vessel flow density of radial peripapillary capillary (RPC) with different courses of disease were compared, and related factors were analyzed with BCVA (LogMAR) and course of disease. Main Outcome Measures BCVA (LogMAR), RNFL thickness, vessel flow density of RPC. Results Compared with the control group（108.67±3.02 μm）, the RNFL thickness of NA-AION group（315.76±21.45 μm） was significantly thicker, and the vessel flow density of RPC was lower at baseline, the difference were statistically significant (all P<0.05). Compared to the eyes with disease duration≤7 days, there were more significant differences in the vessel flow density of RPC between ischemic and non-ischemic areas in the eyes with disease duration>7 days (P<0.05). The BCVA (LogMAR) was improved at 1 month and 3 months after onset, but there was no significant difference in BCVA (LogMAR) between 1 month and 3 months (P=0.329). Compared with the baseline, the RNFL thickness and the vessel flow density of RPC were decreased gradually at 1 month and 3 months the differences were statistically significant (P<0.05). The BCVA (LogMAR) was significantly positively correlated with RNFL thickness and the vessel flow density of RPC (r= 0.527, 0.550; P<0.05). Conclusion We can observe the change of optic disc RNFL thickness and the vessel flow density of RPC in NA-AION by OCTA, and the visual prognosis is significantly correlated with RNFL thickness and the optic disc vessel flow density. (Ophthalmol CHN, 2021, 30: 425-429) |
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| Keywords: | non-arteritic anterior ischemic optic neuropathy optical coherence tomography angiography course of disease vision prognosis |
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