Mouse genetic models for temporomandibular joint development and disorders |
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| Authors: | A Suzuki J Iwata |
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| Affiliation: | 1. Department of Diagnostic & Biomedical Sciences, School of Dentistry, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA;2. Center for Craniofacial Research, UTHealth, Houston, TX, USA |
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| Abstract: | The temporomandibular joint (TMJ) is a synovial joint essential for hinge and sliding movements of the mammalian jaw. Temporomandibular joint disorders (TMD) are dysregulations of the muscles or the TMJ in structure, function, and physiology, and result in pain, limited mandibular mobility, and TMJ noise and clicking. Although approximately 40–70% adults in the USA have at least one sign of TMD, the etiology of TMD remains largely unknown. Here, we highlight recent advances in our understanding of TMD in mouse models. |
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| Keywords: | temporomandibular joint disorders mouse model bones and joints craniofacial developmental disorders genetics |
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