| Experimental Research on Anti-tumor Metastasis Effect of Basil Polysaccharide in vivo |
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| 引用本文： | Qu Xun,Zheng Guang-juan,Liu Fu-li,Zhang Dan,Zhang Jing,Yang Mei-xiang,Xia Li-ying. Experimental Research on Anti-tumor Metastasis Effect of Basil Polysaccharide in vivo[J]. 中国结合医学杂志, 2004, 10(2): 138-140. DOI: 10.1007/BF02836389 |
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| 作者姓名： | Qu Xun Zheng Guang-juan Liu Fu-li Zhang Dan Zhang Jing Yang Mei-xiang Xia Li-ying |
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| 作者单位： | Institute of Basic Medicine，Qilu Hospital of Shandong University，Jinan (250012)，Shandong University of Traditional Chinese Medicine，Institute of Gastroenterology，Shandong Provincial Hospital，Shandong University of Traditional Chinese Medicine，Shandong University of Traditional Chinese Medicine，Institute of Basic Medicine，Qilu Hospital of Shandong University，Jinan (250012)，Shandong University of Traditional Chinese Medicine |
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| 基金项目： | This program was funded by Health Office of Shandong Province (No. 2001CA1CDA1)，Chinese Medicine Bureau of Shandong Province (No. 99 - 46) |
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| 摘 要： | Objective: To study the effects of basil polysaccharide (BP) in inhibiting tumor growth and metastasis in vivo. Methods: One hundred and fifty mice were randomly divided into five groups to observe the effect on tumor growth after H22 cancer cells had been transplanted subcutaneously into their right armpit region and treated with different dosages (5 mg/kg, 2. 5 mg/kg and 1. 25 mg/kg) of BP for 14 days, with Mi-tomycin (Mit-C) used as control. Another 150 mice were randomly divided into three groups, models of tumor metastasis in the lung by various paths (lymphatic, blood circulatory and spontaneous) were established respectively. They were treated with BP or Mit-C to observe the influence of treatments on tumor metastasis by various paths. Results: BP of various dosages showed no effect on tumor growth, but in high and middle dosage, it could significantly reduce the number or metastasis nodules ( P<0. 05). Conclusion: BP has a tumor metastasis inhibitory effect, which might be one of the candidates
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| 收稿时间： | 2003-02-02 |
Experimental research on anti-tumor metastasis effect of basil polysaccharide in vivo |
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| Qu Xun,Zheng Guang-juan,Liu Fu-li,Zhang Dan,Zhang Jing,Yang Mei-xiang and Xia Li-ying. Experimental research on anti-tumor metastasis effect of basil polysaccharide in vivo[J]. Chinese journal of integrative medicine, 2004, 10(2): 138-140. DOI: 10.1007/BF02836389 |
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| Authors: | Qu Xun Zheng Guang-juan Liu Fu-li Zhang Dan Zhang Jing Yang Mei-xiang Xia Li-ying |
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| Affiliation: | (1) Institute of Basic Medicine, Qilu Hospital of Shandong University, 250012 Jinan;(2) Shandong University of Traditional Chinese Medicine, China;(3) Institute of Gastroenterology, Shandong Provincial Hospital, China |
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| Abstract: | Objective: To study the effects of basil polysaccharide (BP) in inhibiting tumor growth and metastasis in vivo. Methods: One hundred and fifty mice were randomly divided into five groups to observe the effect on tumor growth after H22 cancer cells had been transplanted subcutaneously into their right armpit region and treated with different dosages (5 mg/kg, 2.5 mg/kg and 1.25 mg/kg) of BP for 14 days, with Mitomycin (Mit-C) used as control. Another 150 mice were randomly divided into three groups, models of tumor metastasis in the lung by various paths (lymphatic, blood circulatory and spontaneous) were established respectively. They were treated with BP or Mit-C to observe the influence of treatments on tumor metastasis by various paths. Results: BP of various dosages showed no effect on tumor growth, but in high and middle dosage, it could significantly reduce the number or metastasis nodules (P＜0.05). Conclusion: BP has a tumor metastasis inhibitory effect, which might be one of the candidates for new anti-tumor metastasis agents. Its mechanism may be blocking the function of platelets in the tumor metastasis progress. |
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| Keywords: | Chinese medicine basil polysaccharide cell proliferation anti-tumor metastasis |
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