Duplication of segment 1p21 following paternal insertional translocation, ins(6;1)(q25;p13.3p22.1) |
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| Authors: | A. Utkus I. Sorokina V. Kucinskas B. Rothlisberger D. Balmer L. Brecevic A. Schinzel |
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| Affiliation: | Human Genetics Center, University of Vilnius, Lithuania. |
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| Abstract: | A moderately mentally retarded 3 year old boy showed minor anomalies including a prominent forehead and flat occiput, exophthalmos, large and prominent ears, high arched palate, umbilical hernia, sacral dimple, and irregular position of the toes. Cardiac sonography disclosed a chorda running through the left ventricle. Cytogenetic investigation of the family showed a balanced insertional translocation of segment 1p13→p22 into distal 6q in the father which had led, through unbalanced segregation, to duplication of 1p13.3→p22.1 in the proband. Familial duplication of such a small interstitial segment of 1p has not been reported previously, and the paucity of abnormal physical findings in the proband compared to previous patients with a similar aberration is remarkable.
Keywords: chromosome duplication 1p; dual colour FISH; unbalanced insertional translocation |
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| Keywords: | chromosome duplication 1p dual colour FISH unbalanced insertional translocation |
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